Toxoplasma gondii is an obligate intracellular parasite belonging to the phylum
Apicomplexa that infects all warm-blooded animals, including humans. T. gondii can …

Stage conversion is a critical life cycle feature for several Apicomplexan parasites as the
ability to switch between life forms is critical for replication, dissemination, pathogenesis and …

Identification of regulators of Toxoplasma gondii bradyzoite development and cyst formation
is the most direct way to address the importance of parasite development in long-term …

Toxoplasma gondii, a protozoan parasite, undergoes a complex and poorly understood
developmental process that is critical for establishing a chronic infection in its intermediate …

Vaccine discovery against eukaryotic parasites is not trivial as highlighted by the limited
number of known vaccines compared to the number of protozoal diseases that need one …

Pluripotent stem cell-derived cerebral organoids have the potential to recapitulate the
pathophysiology of in vivo human brain tissue, constituting a valuable resource for …

Apicomplexan infections cause substantial morbidity and mortality, worldwide. New,
improved therapies are needed. Herein, we create a next generation anti-apicomplexan …

Toxoplasma gondii transmits through various routes, rapidly proliferates during acute
infection and causes toxoplasmosis, which is an important zoonotic disease in human and …

The first genetic manipulations applied to Toxoplasma gondii were performed in the 1970s
using chemical mutagenesis. These studies were pioneered by developing protocols to …

Alternative splicing is a widespread, essential, and complex component of gene regulation.
Apicomplexan parasites have long been recognized to produce alternatively spliced …