Group 1 metabotropic glutamate receptors in neurological and psychiatric diseases: mechanisms and prospective

LD Su, N Wang, J Han, Y Shen - The Neuroscientist, 2022 - journals.sagepub.com
Metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors that are
activated by glutamate in the central nervous system (CNS). Basically, mGluRs contribute to …

Fundamental mechanisms of autoantibody-induced impairments on ion channels and synapses in immune-mediated cerebellar ataxias

H Mitoma, J Honnorat, K Yamaguchi… - International Journal of …, 2020 - mdpi.com
In the last years, different kinds of limbic encephalitis associated with autoantibodies against
ion channels and synaptic receptors have been described. Many studies have demonstrated …

Transferrin receptor 1-mediated iron uptake plays an essential role in hematopoiesis

S Wang, X He, Q Wu, L Jiang, L Chen, Y Yu… - …, 2019 - pmc.ncbi.nlm.nih.gov
Transferrin receptor 1 (Tfr1) mediates the endocytosis of diferric transferrin in order to
transport iron, and Tfr1 has been suggested to play an important role in hematopoiesis. To …

[HTML][HTML] Purkinje-cell-specific MeCP2 deficiency leads to motor deficits and autistic-like behavior due to aberrations in PTP1B-TrkB-SK signaling

FX Xu, XT Wang, XY Cai, JY Liu, JW Guo, F Yang… - Cell Reports, 2023 - cell.com
Patients with Rett syndrome suffer from a loss-of-function mutation of the Mecp2 gene, which
results in various symptoms including autistic traits and motor deficits. Deletion of Mecp2 in …

CSMD3 deficiency leads to motor impairments and autism-like behaviors via dysfunction of cerebellar purkinje cells in mice

K Xi, SQ Cai, HF Yan, Y Tian, J Cai… - Journal of …, 2023 - Soc Neuroscience
Autism spectrum disorder (ASD) is a neurodevelopmental disorder with highly heritable
heterogeneity. Mutations of CUB and sushi multiple domains 3 (CSMD3) gene have been …

Sustained hyperammonemia activates NF-κB in Purkinje neurons through activation of the TrkB-PI3K-AKT pathway by microglia-derived BDNF in a rat model of …

YM Arenas, V Felipo - Molecular Neurobiology, 2023 - Springer
Chronic hyperammonemia is a main contributor to the cognitive and motor impairment in
patients with hepatic encephalopathy. Sustained hyperammonemia induces the TNFα …

cAMP− EPAC− PKCε− RIM1α signaling regulates presynaptic long-term potentiation and motor learning

XT Wang, L Zhou, BB Dong, FX Xu, DJ Wang… - Elife, 2023 - elifesciences.org
The cerebellum is involved in learning of fine motor skills, yet whether presynaptic plasticity
contributes to such learning remains elusive. Here, we report that the EPAC-PKCε module …

Magneto is ineffective in controlling electrical properties of cerebellar Purkinje cells

FX Xu, L Zhou, XT Wang, F Jia, KY Ma, N Wang… - Nature …, 2020 - nature.com
It was recently reported that a magnetic actuator, Magneto, can control neuronal firings at
magnetic strength as low as 50 mT (ref.), offering an exciting non-invasive approach to …

Ablation of KIF2C in Purkinje cells impairs metabotropic glutamate receptor trafficking and motor coordination in male mice

R Zheng, FX Xu, L Zhou, J Xu, Y Shen… - The Journal of …, 2023 - Wiley Online Library
Kinesin family member 2C (KIF2C)/mitotic centromere‐associated kinesin (MCAK), is
thought to be oncogenic as it is involved in tumour progression and metastasis. Moreover, it …

Ucp4 Knockdown of Cerebellar Purkinje Cells Induces Bradykinesia

YY Wang, H Liu, SJ Li, B Feng, YQ Huang, SB Liu… - Molecular …, 2024 - Springer
Abstract Although uncoupling protein 4 (UCP4) is the most abundant protein reported in the
brain, the biological function of UCP4 in cerebellum and pathological outcome of UCP4 …