A widely distributed gene cluster compensates for uricase loss in hominids

Y Liu, JB Jarman, YS Low, HE Augustijn, S Huang… - Cell, 2023 - cell.com
Approximately 15% of US adults have circulating levels of uric acid above its solubility limit,
which is causally linked to the disease gout. In most mammals, uric acid elimination is …

[HTML][HTML] The AI future of emergency medicine

RJ Petrella - Annals of Emergency Medicine, 2024 - Elsevier
In the coming years, artificial intelligence (AI) and machine learning will likely give rise to
profound changes in the field of emergency medicine, and medicine more broadly. This …

Risks of peri‐and postoperative complications with glucagon‐like peptide‐1 receptor agonists

DC Klonoff, SH Kim, RJ Galindo… - Diabetes, Obesity …, 2024 - Wiley Online Library
Aim To assess whether adults with diabetes on oral hypoglycaemic agents undergoing
general endotracheal anaesthesia during nine common surgical procedures who are …

What complexity science predicts about the potential of artificial intelligence/machine learning to improve primary care

RA Young, CM Martin, JP Sturmberg… - The Journal of the …, 2024 - Am Board Family Med
Primary care physicians are likely both excited and apprehensive at the prospects for
artificial intelligence (AI) and machine learning (ML). Complexity science may provide …

[HTML][HTML] Personalizing cholesterol treatment recommendations for primary cardiovascular disease prevention

A Sarraju, A Ward, J Li, A Valencia, L Palaniappan… - Scientific Reports, 2022 - nature.com
Statin therapy is the cornerstone of preventing atherosclerotic cardiovascular disease
(ASCVD), primarily by reducing low density lipoprotein cholesterol (LDL-C) levels. Optimal …

[HTML][HTML] Building a learning health system: creating an analytical workflow for evidence generation to inform institutional clinical care guidelines

D Dash, A Gokhale, BS Patel… - Applied Clinical …, 2022 - thieme-connect.com
Background One key aspect of a learning health system (LHS) is utilizing data generated
during care delivery to inform clinical care. However, institutional guidelines that utilize …

Detection and Grading of Radiographic Hand Osteoarthritis Using an Automated Machine Learning Platform

L Caratsch, C Lechtenboehmer, M Caorsi… - ACR Open …, 2024 - Wiley Online Library
Objective Automated machine learning (autoML) platforms allow health care professionals
to play an active role in the development of machine learning (ML) algorithms according to …

[HTML][HTML] Real-world evidence supports higher prevalence of heart failure among persons with type 1 and type 2 diabetes compared with the general population

V Garrett, S Gombar, J Huang, AM Yeung… - Journal of Diabetes …, 2023 - ncbi.nlm.nih.gov
1. Dunlay SM, Givertz MM, Aguilar D, et al. Type 2 diabetes mellitus and heart failure: a
scientific statement from the American Heart Association and the Heart Failure Society of …

Precision emergency medicine

M Strehlow, A Alvarez, AL Blomkalns… - Academic …, 2024 - Wiley Online Library
Background Precision health is a burgeoning scientific discipline that aims to incorporate
individual variability in biological, behavioral, and social factors to develop personalized …

Answering real-world clinical questions using large language model based systems

YS Low, ML Jackson, RJ Hyde, RE Brown… - arXiv preprint arXiv …, 2024 - arxiv.org
Evidence to guide healthcare decisions is often limited by a lack of relevant and trustworthy
literature as well as difficulty in contextualizing existing research for a specific patient. Large …