Modifications of RNA affect its function and stability. RNA editing is unique among these
modifications because it not only alters the cellular fate of RNA molecules but also alters …

The advantages of the model organism Drosophila melanogaster, including low genetic
redundancy, functional simplicity, and the ability to conduct large-scale genetic screens …

The needs fulfilled by sleep are unknown, though the effects of insufficient sleep are
manifold. To better understand how the need to sleep is sensed and discharged, much effort …

Despite decades of intense study, the functions of sleep are still shrouded in mystery. The
difficulty in understanding these functions can be at least partly attributed to the varied …

One of the most prevalent forms of post-transcritpional RNA modification is the conversion of
adenosine nucleosides to inosine (A-to-I), mediated by the ADAR family of enzymes. The …

Post-transcriptional modifications have been recently expanded with the addition of RNA
editing, which is predominantly mediated by adenosine and cytidine deaminases acting on …

Sleep is homeostatically regulated with sleep pressure accumulating with the increasing
duration of prior wakefulness. Yet, a clear understanding of the molecular components of the …

We review the structures and functions of ADARs and their involvements in human diseases.
ADAR1 is widely expressed, particularly in the myeloid component of the blood system, and …

Posttranscriptional RNA modifications by adenosine-to-inosine (A-to-I) editing are abundant
in the brain, yet elucidating functional sites remains challenging. To bridge this gap, we …

Numerous human diseases arise from alterations of genetic information, most notably DNA
mutations. Thought to be merely the intermediate between DNA and protein, changes in …