Despite advances in machine learning-based protein structure prediction, we are still far
from fully understanding how proteins fold into their native conformation. The conventional …

Introduction Protein misfolding diseases, including Alzheimer's and Parkinson's diseases,
are characterized by the aberrant aggregation of proteins. These conditions are still largely …

Aging is characterized by loss of proteostasis and mitochondrial homeostasis. Here, we
provide bioinformatic evidence of dysregulation of mitochondrial and proteostasis pathways …

A long-standing goal of amyloid research has been to characterize the structural basis of the
rate-determining nucleating event. However, the ephemeral nature of nucleation has made …

During aging, proteostasis capacity declines and distinct proteins become unstable and can
accumulate as protein aggregates inside and outside of cells. Both in disease and during …

In metazoans, the secreted proteome participates in intercellular signalling and innate
immunity, and builds the extracellular matrix scaffold around cells. Compared with the …

Quantitative micromechanical characterization of single cells and multicellular tissues or
organisms is of fundamental importance to the study of cellular growth, morphogenesis, and …

The plastic architecture of the mitochondrial network and its dynamic structure play crucial
roles ensuring that varying energetic demands are rapidly met. Given the brain's high …

Protein aggregation, which can sometimes spread in a prion-like manner, is a hallmark of
neurodegenerative diseases. However, whether prion-like aggregates form during normal …

Protein aggregation is a hallmark of age-related neurodegeneration. Yet, aggregation
during normal aging and in tissues other than the brain is poorly understood. Here, we …