Expectations on mesenchymal stem cell (MSC) treatment are high, especially in the fields of
sepsis, transplant medicine, and autoimmune diseases. Various pre-clinical studies have …

Mesenchymal stem cells (MSCs; also referred to as mesenchymal stromal cells) have
attracted much attention for their ability to regulate inflammatory processes. Their therapeutic …

Melatonin is a pleotropic molecule with numerous biological activities. Epidemiological and
experimental studies have documented that melatonin could inhibit different types of cancer …

Insomnia is a serious worldwide health threat, affecting nearly one third of the general
population. Melatonin has been reported to improve sleep efficiency and it was found that …

We tested the hypothesis that combined xenogenic (from mini-pig) adipose-derived
mesenchymal stem cell (ADMSC) and ADMSC-derived exosome therapy could reduce brain …

Background In this study, we tested the hypothesis that a combined adipose-derived
mesenchymal stem cell (ADMSC) and ADMSC-derived exosome therapy protected rat …

Mesenchymal stem cells (MSCs) derived exosomes have been shown to have protective
effects on the kidney in ischemia/reperfusion‐induced renal injury. However, the key …

Background Ferroptosis is a regulated form of cell death. At present, the role of ferroptosis in
sepsis-induced acute kidney injury (SAKI) has not been studied. Melatonin (MEL) has been …

Sepsis is a systemic inflammatory response to infection that causes severe neurological
complications. Previous studies have suggested that melatonin is protective during sepsis …

Melatonin reportedly alleviates sepsis-induced multi-organ injury by inducing autophagy
and activating class III deacetylase Sirtuin family members (SIRT1–7). However, whether …