Emerging diversity in lipid–protein interactions
Membrane lipids interact with proteins in a variety of ways, ranging from providing a stable
membrane environment for proteins to being embedded in to detailed roles in complicated …
membrane environment for proteins to being embedded in to detailed roles in complicated …
Characterization of lipid–protein interactions and lipid-mediated modulation of membrane protein function through molecular simulation
The cellular membrane constitutes one of the most fundamental compartments of a living
cell, where key processes such as selective transport of material and exchange of …
cell, where key processes such as selective transport of material and exchange of …
Atomistic simulations of membrane ion channel conduction, gating, and modulation
Membrane ion channels are the fundamental electrical components in the nervous system.
Recent developments in X-ray crystallography and cryo-EM microscopy have revealed what …
Recent developments in X-ray crystallography and cryo-EM microscopy have revealed what …
Sodium channels and local anesthetics—old friends with new perspectives
J Körner, S Albani… - Frontiers in …, 2022 - frontiersin.org
The long history of local anesthetics (LAs) starts out in the late 19th century when the content
of coca plant leaves was discovered to alleviate pain. Soon after, cocaine was established …
of coca plant leaves was discovered to alleviate pain. Soon after, cocaine was established …
Local anesthetic and antiepileptic drug access and binding to a bacterial voltage-gated sodium channel
Voltage-gated sodium (Nav) channels are important targets in the treatment of a range of
pathologies. Bacterial channels, for which crystal structures have been solved, exhibit …
pathologies. Bacterial channels, for which crystal structures have been solved, exhibit …
The effects of general anesthetics on synaptic transmission
X Hao, M Ou, D Zhang, W Zhao, Y Yang… - Current …, 2020 - ingentaconnect.com
General anesthetics are a class of drugs that target the central nervous system and are
widely used for various medical procedures. General anesthetics produce many behavioral …
widely used for various medical procedures. General anesthetics produce many behavioral …
[HTML][HTML] Bacterial voltage-gated sodium channels (BacNaVs) from the soil, sea, and salt lakes enlighten molecular mechanisms of electrical signaling and …
J Payandeh, DL Minor Jr - Journal of molecular biology, 2015 - Elsevier
Voltage-gated sodium channels (Na V s) provide the initial electrical signal that drives action
potential generation in many excitable cells of the brain, heart, and nervous system. For …
potential generation in many excitable cells of the brain, heart, and nervous system. For …
Characterizing fenestration size in sodium channel subtypes and their accessibility to inhibitors
Voltage-gated sodium channels (Nav) underlie the electrical activity of nerve and muscle
cells. Humans have nine different subtypes of these channels, which are the target of small …
cells. Humans have nine different subtypes of these channels, which are the target of small …
Mechanistic insights into the modulation of voltage-gated ion channels by inhalational anesthetics
M Covarrubias, AF Barber, V Carnevale, W Treptow… - Biophysical journal, 2015 - cell.com
General anesthesia is a relatively safe medical procedure, which for nearly 170 years has
allowed life saving surgical interventions in animals and people. However, the molecular …
allowed life saving surgical interventions in animals and people. However, the molecular …
Protonation state of inhibitors determines interaction sites within voltage-gated sodium channels
Voltage-gated sodium channels are essential for carrying electrical signals throughout the
body, and mutations in these proteins are responsible for a variety of disorders, including …
body, and mutations in these proteins are responsible for a variety of disorders, including …