Therapeutic efficacy of artemether-lumefantrine, artesunate-amodiaquine and dihydroartemisinin-piperaquine in the treatment of uncomplicated Plasmodium …
Background Sub-Saharan Africa has the highest burden of malaria in the world. Artemisinin-
based combination therapies (ACTs) have been the cornerstone in the efforts to reduce the …
based combination therapies (ACTs) have been the cornerstone in the efforts to reduce the …
Deployment and utilization of next-generation sequencing of Plasmodium falciparum to guide anti-malarial drug policy decisions in sub-Saharan Africa: opportunities …
DS Ishengoma, Q Saidi, CH Sibley, C Roper… - Malaria journal, 2019 - Springer
Parasite resistance against anti-malarial drugs is a major threat to the ongoing malaria
control and elimination strategies. This is especially true since resistance to the currently …
control and elimination strategies. This is especially true since resistance to the currently …
Evidence of artemisinin partial resistance in northwestern Tanzania: clinical and molecular markers of resistance
Background In 2021, nationwide malaria molecular surveillance revealed a high prevalence
of a validated artemisinin resistance marker, the kelch13 (k13) Arg561His mutation, in the …
of a validated artemisinin resistance marker, the kelch13 (k13) Arg561His mutation, in the …
Mutation in the Plasmodium falciparum BTB/POZ domain of K13 protein confers artemisinin resistance
Partial artemisinin resistance, defined in patients as a delayed parasite clearance following
artemisinin-based treatment, is conferred by non-synonymous mutations in the Kelch beta …
artemisinin-based treatment, is conferred by non-synonymous mutations in the Kelch beta …
Artesunate–amodiaquine and artemether–lumefantrine for the treatment of uncomplicated falciparum malaria in Liberia: in vivo efficacy and frequency of molecular …
VS Koko, M Warsame, B Vonhm, MK Jeuronlon… - Malaria Journal, 2022 - Springer
Background Artesunate–amodiaquine (ASAQ) and Artemether–lumefantrine (AL) are the
recommended treatment for uncomplicated Plasmodium falciparum malaria in Liberia …
recommended treatment for uncomplicated Plasmodium falciparum malaria in Liberia …
Prevalence of potential mediators of artemisinin resistance in African isolates of Plasmodium falciparum
Background The devastating public health impact of malaria has prompted the need for
effective interventions. Malaria control gained traction after the introduction of artemisinin …
effective interventions. Malaria control gained traction after the introduction of artemisinin …
Plasmodium falciparum kelch propeller polymorphisms in clinical isolates from Ghana from 2007 to 2016
SA Matrevi, P Opoku-Agyeman… - Antimicrobial agents …, 2019 - Am Soc Microbiol
The continuous surveillance of polymorphisms in the kelch propeller domain of Plasmodium
falciparum from Africa is important for the discovery of the actual markers of artemisinin …
falciparum from Africa is important for the discovery of the actual markers of artemisinin …
[HTML][HTML] Evidence of artemisinin partial resistance in North-western Tanzania: clinical and drug resistance markers study
Background: Artemisinin-based combination therapies (ACTs) are the recommended
antimalarial drugs for the treatment of uncomplicated malaria. The recent emergence of …
antimalarial drugs for the treatment of uncomplicated malaria. The recent emergence of …
Therapeutic efficacy of artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Chewaka District, Ethiopia
A Abamecha, D Yilma, W Addisu, H El-Abid, A Ibenthal… - Malaria Journal, 2020 - Springer
Background The efficacy of artemether-lumefantrine (AL) for treatment of uncomplicated
Plasmodium falciparum malaria in south-western Ethiopia is poorly documented. Regular …
Plasmodium falciparum malaria in south-western Ethiopia is poorly documented. Regular …
Trends of Plasmodium falciparum molecular markers associated with resistance to artemisinins and reduced susceptibility to lumefantrine in Mainland Tanzania from …
Abstract Background Therapeutic efficacy studies (TESs) and detection of molecular
markers of drug resistance are recommended by the World Health Organization (WHO) to …
markers of drug resistance are recommended by the World Health Organization (WHO) to …