Western diets and chronic diseases

TE Adolph, H Tilg - Nature medicine, 2024 - nature.com
Abstract 'Westernization', which incorporates industrial, cultural and dietary trends, has
paralleled the rise of noncommunicable diseases across the globe. Today, the Western-style …

[HTML][HTML] Pathobionts in inflammatory bowel disease: origins, underlying mechanisms, and implications for clinical care

A Gilliland, JJ Chan, TJ De Wolfe, H Yang, BA Vallance - Gastroenterology, 2024 - Elsevier
The gut microbiota plays a significant role in the pathogenesis of both forms of inflammatory
bowel disease (IBD), namely Crohn's disease (CD) and ulcerative colitis (UC). While …

Examining the healthy human microbiome concept

R Joos, K Boucher, A Lavelle, M Arumugam… - Nature Reviews …, 2024 - nature.com
Human microbiomes are essential to health throughout the lifespan and are increasingly
recognized and studied for their roles in metabolic, immunological and neurological …

Fiber-deficient diet inhibits colitis through the regulation of the niche and metabolism of a gut pathobiont

P Kuffa, JM Pickard, A Campbell, M Yamashita… - Cell Host & Microbe, 2023 - cell.com
Exclusive enteral nutrition (EEN) with fiber-free diets is an effective steroid-sparing treatment
to induce clinical remission in children with Crohn's disease (CD). However, the mechanism …

Deciphering the different phases of preclinical inflammatory bowel disease

JJ Rudbaek, M Agrawal, J Torres… - Nature Reviews …, 2024 - nature.com
Inflammatory bowel disease (IBD) is an immune-mediated inflammatory disease (IMID) of
the gastrointestinal tract and includes two subtypes: Crohn's disease and ulcerative colitis. It …

Diet and microbiome-directed therapy 2.0 for IBD

AN Ananthakrishnan, K Whelan, JR Allegretti… - Clinical …, 2024 - Elsevier
Inflammatory bowel disease (IBD) are chronic and relapsing disorders of the gastrointestinal
tract, characterized by dysregulated immune responses to the gut microbiome. The gut …

Integrating multi-omics to unravel host-microbiome interactions in inflammatory bowel disease

Y Zhang, JP Thomas, T Korcsmaros, L Gul - Cell Reports Medicine, 2024 - cell.com
The gut microbiome is crucial for nutrient metabolism, immune regulation, and intestinal
homeostasis with changes in its composition linked to complex diseases like inflammatory …

Host–pathobiont interactions in Crohn's disease

R Caruso, BC Lo, GY Chen, G Núñez - … Reviews Gastroenterology & …, 2024 - nature.com
The mammalian intestine is colonized by trillions of microorganisms that are collectively
referred to as the gut microbiota. The majority of symbionts have co-evolved with their host in …

AGA Clinical Practice Guideline on Fecal Microbiota–Based Therapies for Select Gastrointestinal Diseases

AF Peery, CR Kelly, D Kao, BP Vaughn, B Lebwohl… - Gastroenterology, 2024 - Elsevier
Background & Aims Fecal microbiota–based therapies include conventional fecal microbiota
transplant and US Food and Drug Administration–approved therapies, fecal microbiota live …

Harnessing human microbiomes for disease prediction

Y Liu, M Fachrul, M Inouye, G Méric - Trends in microbiology, 2024 - cell.com
The human microbiome has been increasingly recognized as having potential use for
disease prediction. Predicting the risk, progression, and severity of diseases holds promise …