Pancreatic cancer is an aggressive malignancy with increasing incidence and poor
prognosis due to its late diagnosis and intrinsic chemoresistance. Most pancreatic cancer …

Lithium has literally been everywhere forever, since it is one of the three elements created in
the Big Bang. Lithium concentration in rocks, soil, and fresh water is highly variable from …

A delicate equilibrium of WNT agonists and antagonists in the intestinal stem cell (ISC) niche
is critical to maintaining the ISC compartment, as it accommodates the rapid renewal of the …

Background Triple-negative breast cancers (TNBCs), which lack receptors for estrogen,
progesterone, and amplification of epidermal growth factor receptor 2, are highly aggressive …

Abstract Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase that participates
in an array of critical cellular processes. GSK-3 was first characterized as an enzyme that …

Molybdenum, lithium, and tungsten are constituents of many products, and exposure to
these elements potentially occurs at work. Therefore it is important to determine at what …

Lithium (Li) is a metal with critical therapeutic properties ranging from the treatment of
bipolar depression to antibacterial, anticancer, antiviral and pro-regenerative effects. This …

Glycogen synthase kinase (GSK) 3β is a multifunctional serine/threonine protein kinase with
more than 100 substrates and interacting molecules. GSK3β is normally active in cells and …

The Wnt signaling pathway is a highly conserved regulator of metazoan development and
stem cell maintenance. Activation of Wnt signaling is an early step in diverse malignancies …

Mounting evidence indicates that Wnt signaling is relevant to pathophysiology of diverse
mental illnesses including schizophrenia, bipolar disorder, and autism spectrum disorder. In …