Oligodendrocytes generate multiple layers of myelin membrane around axons of the central
nervous system to enable fast and efficient nerve conduction. Until recently, saltatory nerve …

Myelin is critical for the proper function of the nervous system and one of the most complex
cell–cell interactions of the body. Myelination allows for the rapid conduction of action …

UDP-glycosyltransferases (UGTs) catalyze the covalent addition of sugars to a broad range
of lipophilic molecules. This biotransformation plays a critical role in elimination of a broad …

Myelinated nerve fibers have evolved to enable fast and efficient transduction of electrical
signals in the nervous system. To act as an electric insulator, the myelin sheath is formed as …

Myelination of axons in the nervous system of vertebrates enables fast, saltatory impulse
propagation, one of the best-understood concepts in neurophysiology. However, it took a …

Abstract Properties of human brain tissue change across the lifespan. Here we model these
changes in the living human brain by combining quantitative magnetic resonance imaging …

Background Human genetic association studies point to immune response and lipid
metabolism, in addition to amyloid-beta (Aβ) and tau, as major pathways in Alzheimer's …

Much has been made about JLW Thudichum's colorful, and one could say clairvoyant,
naming of sphingosine “in commemoration of the many enigmas which it presented to the …

Oligodendrocytes, the myelin-forming cells of the central nervous system (CNS), and
astrocytes constitute macroglia. This review deals with the recent progress related to the …

Major depression and anxiety disorders have high prevalence rates and are frequently
comorbid. The neurobiological bases for these disorders are not fully understood, and …