Blood-derived biomarkers for brain and spinal cord diseases are urgently needed. The
introduction of highly sensitive immunoassays led to a rapid increase in the number of …

It has been 15 years since the birth of human induced pluripotent stem cell (iPSC)
technology in 2007, and the scope of its application has been expanding. In addition to the …

Fifty years have passed since the discovery of glial fibrillary acidic protein (GFAP) by
Lawrence Eng and colleagues. Now recognized as a member of the intermediate filament …

Background Plasma glial fibrillary acidic protein (GFAP) has emerged as a promising
biomarker in neurological disorders, but further evidence is required in relation to its …

Alexander disease is a primary disorder of astrocytes caused by gain-of-function mutations
in the gene for glial fibrillary acidic protein (GFAP), which lead to protein aggregation and a …

ABSTRACT HIV-1 infection within the central nervous system (CNS) includes evolution of
the virus, damaging inflammatory cascades, and the involvement of multiple cell types; …

Alexander disease (AxD) is a devastating leukodystrophy caused by gain-of-function
mutations in GFAP, and the only available treatments are supportive. Recent advances in …

Intermediate filaments (IFs) play key roles in cell mechanics, signaling and homeostasis.
Their assembly and dynamics are finely regulated by posttranslational modifications. The …

TDP-43 proteinopathies including frontotemporal lobar degeneration (FTLD) and
amyotrophic lateral sclerosis (ALS) are neurodegenerative disorders characterized by …

Neurofilaments (NFs) and GFAP are cytoskeletal intermediate filaments (IFs) that support
cellular processes unfolding within the uniquely complex environments of neurons and …