Skeletal muscle deconditioning in breast cancer patients undergoing chemotherapy: current knowledge and insights from other cancers

J Mallard, E Hucteau, TJ Hureau… - Frontiers in Cell and …, 2021 - frontiersin.org
Breast cancer represents the most commonly diagnosed cancer while neoadjuvant and
adjuvant chemotherapies are extensively used in order to reduce tumor development and …

Small non‐coding RNA profiling in patients with gastrointestinal cancer

A Molfino, M Beltrà, MI Amabile, R Belli… - Journal of Cachexia …, 2023 - Wiley Online Library
Background Small non‐coding (snc) RNAs, including microRNAs and P‐element induced
wimpy testis (PIWI)‐interacting‐RNAs (piRNAs), crucially regulate gene expression in both …

[HTML][HTML] Skeletal muscle-specific overexpression of miR-486 limits mammary tumor-induced skeletal muscle functional limitations

R Wang, B Kumar, EH Doud, AL Mosley… - … Therapy-Nucleic Acids, 2022 - cell.com
miR-486 is a myogenic microRNA, and its reduced skeletal muscle expression is observed
in muscular dystrophy. Transgenic overexpression of miR-486 using muscle creatine kinase …

A human skeletal muscle stem/myotube model reveals multiple signaling targets of cancer secretome in skeletal muscle

R Wang, B Kumar, P Bhat-Nakshatri, AS Khatpe… - Iscience, 2023 - cell.com
Skeletal muscle dysfunction or reprogramming due to the effects of the cancer secretome is
observed in multiple malignancies. Although mouse models are routinely used to study …

Hormonally regulated myogenic miR-486 influences sex-specific differences in cancer-induced skeletal muscle defects

R Wang, P Bhat-Nakshatri, X Zhong, T Zimmers… - …, 2021 - academic.oup.com
Cancer-induced skeletal muscle defects show sex-specific differences in severity with men
performing poorly compared to women. Hormones and sex chromosomal differences are …

Mutant RAS-driven Secretome Causes Skeletal Muscle Defects in Breast Cancer

R Wang, AS Khatpe, B Kumar, HE Mang, K Batic… - Cancer Research …, 2024 - AACR
Cancer-induced skeletal muscle defects differ in severity between individuals with the same
cancer type. Cancer subtype-specific genomic aberrations are suggested to mediate these …