In the early years of the molecular biology revolution, cancer research was mainly focused on genetic changes (ie, those that altered DNA sequences). Although this has been …
LA MacFarlane, PR Murphy - Current genomics, 2010 - ingentaconnect.com
MicroRNAs are small, highly conserved non-coding RNA molecules involved in the regulation of gene expression. MicroRNAs are transcribed by RNA polymerases II and III …
R Hummel, DJ Hussey, J Haier - European journal of cancer, 2010 - Elsevier
MicroRNAs (miRNAs) represent a class of naturally occurring small non-coding RNA molecules. They regulate gene expression at the post-transcriptional level and control …
O Slaby, M Svoboda, J Michalek, R Vyzula - Molecular cancer, 2009 - Springer
MicroRNAs (miRNAs) are small non-coding RNAs 18-25 nucleotides in length that downregulate gene expression during various crucial cell processes such as apoptosis …
Molecular diagnostics in cancer should provide the highest specificity and sensitivity in classification, prognostic stratification and early detection. miRNAs could contribute to hitting …
Background Advances in high-throughput technologies and bioinformatics have transformed gene expression profiling methodologies. The results of microarray experiments are often …
X Zhu, Y Li, H Shen, H Li, L Long, L Hui, W Xu - FEBS letters, 2013 - Elsevier
MicroRNAs (miRNA) have emerged as key players in carcinogenesis. Here, we investigated the role of miR-137 in the pathogenesis of lung cancer. The downregulation of miR-137 in …
Y Chi, D Zhou - Journal of Experimental & Clinical Cancer Research, 2016 - Springer
Background Acting as inflammatory mediators, tumor oncogenes or suppressors, microRNAs are involved in cell survival, death, epithelial–mesenchymal transition and …
GDV Scarpati, F Falcetta, C Carlomagno… - International journal of …, 2012 - Elsevier
PURPOSE: MicroRNAs (miRNAs) are small, noncoding RNA molecules that can be down-or upregulated in colorectal cancer and have been associated to prognosis and response to …