Neuronal cell death
M Fricker, AM Tolkovsky, V Borutaite… - Physiological …, 2018 - journals.physiology.org
Neuronal cell death occurs extensively during development and pathology, where it is
especially important because of the limited capacity of adult neurons to proliferate or be …
especially important because of the limited capacity of adult neurons to proliferate or be …
Programmed axon degeneration: from mouse to mechanism to medicine
MP Coleman, A Höke - Nature Reviews Neuroscience, 2020 - nature.com
Wallerian degeneration is a widespread mechanism of programmed axon degeneration. In
the three decades since the discovery of the Wallerian degeneration slow (Wld S) mouse …
the three decades since the discovery of the Wallerian degeneration slow (Wld S) mouse …
[HTML][HTML] Small molecule SARM1 inhibitors recapitulate the SARM1−/− phenotype and allow recovery of a metastable pool of axons fated to degenerate
RO Hughes, T Bosanac, X Mao, TM Engber… - Cell reports, 2021 - cell.com
Axonal degeneration is responsible for disease progression and accumulation of disability
in many neurodegenerative conditions. The axonal degenerative process can generate a …
in many neurodegenerative conditions. The axonal degenerative process can generate a …
Dynamic recruitment and activation of ALS-associated TBK1 with its target optineurin are required for efficient mitophagy
AS Moore, ELF Holzbaur - Proceedings of the National …, 2016 - National Acad Sciences
Mitochondria play an essential role in maintaining cellular homeostasis. The removal of
damaged or depolarized mitochondria occurs via mitophagy, in which damaged …
damaged or depolarized mitochondria occurs via mitophagy, in which damaged …
[HTML][HTML] SARM1 acts downstream of neuroinflammatory and necroptotic signaling to induce axon degeneration
Neuroinflammation and necroptosis are major contributors to neurodegenerative disease,
and axon dysfunction and degeneration is often an initiating event. SARM1 is the central …
and axon dysfunction and degeneration is often an initiating event. SARM1 is the central …
Axon self-destruction: new links among SARM1, MAPKs, and NAD+ metabolism
Wallerian axon degeneration is a form of programmed subcellular death that promotes axon
breakdown in disease and injury. Active degeneration requires SARM1 and MAP kinases …
breakdown in disease and injury. Active degeneration requires SARM1 and MAP kinases …
SARM1 activation triggers axon degeneration locally via NAD+ destruction
Axon degeneration is an intrinsic self-destruction program that underlies axon loss during
injury and disease. Sterile alpha and TIR motif–containing 1 (SARM1) protein is an essential …
injury and disease. Sterile alpha and TIR motif–containing 1 (SARM1) protein is an essential …
Targeting synapse function and loss for treatment of neurodegenerative diseases
Synapse dysfunction and loss are hallmarks of neurodegenerative diseases that correlate
with cognitive decline. However, the mechanisms and therapeutic strategies to prevent or …
with cognitive decline. However, the mechanisms and therapeutic strategies to prevent or …
Structural basis for SARM1 inhibition and activation under energetic stress
M Sporny, J Guez-Haddad, T Khazma, A Yaron… - Elife, 2020 - elifesciences.org
SARM1, an executor of axonal degeneration, displays NADase activity that depletes the key
cellular metabolite, NAD+, in response to nerve injury. The basis of SARM1 inhibition and its …
cellular metabolite, NAD+, in response to nerve injury. The basis of SARM1 inhibition and its …
[HTML][HTML] Pathological axonal death through a MAPK cascade that triggers a local energy deficit
Axonal death disrupts functional connectivity of neural circuits and is a critical feature of
many neurodegenerative disorders. Pathological axon degeneration often occurs …
many neurodegenerative disorders. Pathological axon degeneration often occurs …