Executive summary The number of older people, including those living with dementia, is
rising, as younger age mortality declines. However, the age-specific incidence of dementia …

Approximately 10% of dementia patients have idiopathic normal pressure hydrocephalus
(iNPH), an expansion of the cerebrospinal fluid (CSF)-filled brain ventricles. iNPH and …

Por que os grandes gurus do Vale do Silício proíbem seus filhos de usar telas? Você sabia
que nunca na história da humanidade houve um declínio tão acentuado nas habilidades …

Introduction We evaluated the clinical profile of the orexin receptor antagonist suvorexant for
treating insomnia in patients with mild‐to‐moderate probable Alzheimer's disease (AD) …

Pathological proteins contributing to Alzheimer's disease (AD) are known to disrupt normal
neuronal functions in the brain, leading to unbalanced neuronal excitatory-inhibitory tone …

Modulation of basic biochemical and physiological processes by the circadian timing system
is now recognized as a fundamental feature of all mammalian organ systems. Within the …

The movement of fluid into, through, and out of the brain plays an important role in clearing
metabolic waste. However, there is controversy regarding the mechanisms driving fluid …

Introduction Alzheimer's disease (AD) is a progressive neurodegenerative disorder. Current
core cerebrospinal fluid (CSF) AD biomarkers, widely employed for diagnosis, require a …

Introduction Previous research has identified a link between sleep disturbances and
cognitive impairment; however, no study has examined this relationship using a national …

Despite the considerable progress made towards understanding ALS pathophysiology,
several key features of ALS remain unexplained, from its aetiology to its epidemiological …