Recent technological advances allow for high throughput profiling of biological systems in a
cost‐efficient manner. The low cost of data generation is leading us to the “big data” era. The …

Recent advances in fast and inexpensive DNA sequencing have enabled the extensive
study of genomic and transcriptomic variation in humans. Human genomic variation is …

Summary cis-regulatory elements (CREs) encode the genomic blueprints of spatiotemporal
gene expression programs enabling highly specialized cell functions. Using single-cell …

Models for predicting phenotypic outcomes from genotypes have important applications to
understanding genomic function and improving human health. Here, we develop a machine …

The human genome encodes the blueprint of life, but the function of the vast majority of its
nearly three billion bases is unknown. The Encyclopedia of DNA Elements (ENCODE) …

Transcription factors bind in a combinatorial fashion to specify the on-and-off states of
genes; the ensemble of these binding events forms a regulatory network, constituting the …

Background Although draft genomes are available for most agronomically important plant
species, the majority are incomplete, highly fragmented, and often riddled with assembly …

Algorithms that accurately predict gene structure from primary sequence alone were
transformative for annotating the human genome. Can we also predict the expression levels …

The genetic changes underlying the dramatic differences in form and function between
humans and other primates are largely unknown, although it is clear that gene regulatory …

One goal of human genetics is to understand how the information for precise and dynamic
gene expression programs is encoded in the genome. The interactions of transcription …