Abstract Alzheimer's disease (AD), a progressive neurodegenerative disorder, is
characterized by the deficits in the cholinergic system and deposition of beta amyloid (Aβ) in …

Compounds incorporating the chromene scaffold are largely present in natural products and
display a wide variety of biological activities. Their low toxicity combined to the broad …

Acetylcholinesterase (AChE) enzyme inhibition is an important target for the management of
Alzheimer disease (AD) and AChE inhibitors are the main stay drugs for its management …

With 27 million cases worldwide documented in 2006, Alzheimer's disease (AD) constitutes
an overwhelming health, social, economic, and political problem to nations. Unless a new …

Alzheimerβs disease (AD) is a multifactorial neurodegenerative disorder with several target
proteins contributing to its aetiology. Pathological, genetic, biochemical, and modeling …

A series of novel piperazine tethered biphenyl-3-oxo-1, 2, 4-triazine derivatives were
designed, and synthesized. Amongst the synthesized analogs, compound 6g showed …

Flavonoids are one of the largest classes of plant secondary metabolites and are known to
possess a number of significant biological activities for human health. In this study, we …

The first report in literature of the isolation of coumarin was in the year 1820. After this report,
other papers were published demonstrating the isolation and synthesis of coumarin and …

The therapeutic arsenal for the treatment of Alzheimer s disease (AD) remains confined to a
group of four inhibitors of AChE and one NMDA receptor antagonist, which are used to …

The complex etiology of Alzheimer's disease (AD) prompts scientists to develop
multifunctional compounds to combat causes and symptoms of such neurodegeneration. To …