The Transforming Growth Factor-beta (TGF-β) family plays relevant roles in the regulation of
different cellular processes that are essential for tissue and organ homeostasis. In the case …

The transforming growth factor‐beta (TGF‐β) family signalling pathways play essential roles
in the regulation of different cellular processes, including proliferation, differentiation …

Transforming growth factor-β (TGF-β) is a cytokine essential for the induction of the fibrotic
response and for the activation of the cancer stroma. Strong evidence suggests that a strong …

Tumor metastasis is not only a sign of disease severity but also a major factor causing
treatment failure and cancer-related death. Therefore, studies on the molecular mechanisms …

This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …

Epithelial cancers make up the vast majority of cancer types and, during the transition from
benign adenoma to malignant carcinoma and metastasis, epithelial tumor cells acquire a de …

Simple Summary The tumor microenvironment plays an important role in determining the
biological behavior of several of the more aggressive malignancies. Among the various cell …

The transforming growth factor-beta (TGF-!) belongs to a superfamily of cytokines that act on
protein kinase receptors at the plasma membrane to induce a plethora of biological signals …

Hepatocellular carcinoma (HCC) is a major health problem, being the sixth most common
cancer world-wide. Dysregulation of the balance between proliferation and cell death …

BACKGROUND/AIMS: The transforming growth factor-beta (TGF-β) induces apoptosis in
hepatocytes through an oxidative stress process. Here, we have analyzed the role of …