In mammals, DNA methylation in the form of 5-methylcytosine (5mC) can be actively
reversed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to …

The pattern of DNA methylation at cytosine bases in the genome is tightly linked to gene
expression, and DNA methylation abnormalities are often observed in diseases. The ten …

The striatum contributes to many cognitive processes and disorders, but its cell types are
incompletely characterized. We show that microfluidic and FACS-based single-cell RNA …

Hydroxymethylcytosine (5hmC) is an important mammalian DNA epigenetic modification
that has been linked to gene regulation and cancer pathogenesis. Here we explored the …

Ten-eleven translocation (TET) family proteins (TETs), specifically, TET1, TET2 and TET3,
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …

Mature neurons in the adult peripheral nervous system can effectively switch from a dormant
state with little axonal growth to robust axon regeneration upon injury. The mechanisms by …

The past decade has witnessed a number of societal and political changes that have raised
critical questions about the long-term impact of marijuana (Cannabis sativa) that are …

Extensive debates continue regarding marijuana (Cannabis spp), the most commonly used
illicit substance in many countries worldwide. There has been an exponential increase of …

Neuroepigenetics is a newly emerging field in neurobiology that addresses the epigenetic
mechanism of gene expression regulation in various postmitotic neurons, both over time and …

Drug addiction involves long-term behavioral abnormalities that arise in response to
repeated exposure to drugs of abuse in vulnerable individuals. It is a multifactorial syndrome …