Epithelial‐to‐mesenchymal transition in oral squamous cell carcinoma: challenges and opportunities

Z Ling, B Cheng, X Tao - International journal of cancer, 2021 - Wiley Online Library
Oral squamous cell carcinoma (OSCC) is the most common malignancy representing 90%
of all forms of oral cancer worldwide. Although great efforts have been made in the past …

The role of Hedgehog signaling pathway in head and neck squamous cell carcinoma

P Cierpikowski, A Leszczyszyn, J Bar - Cells, 2023 - mdpi.com
Head and neck squamous cell carcinoma (HNSCC) is the sixth leading malignancy
worldwide, with a poor prognosis and limited treatment options. Molecularly targeted …

Multifactorial contribution of notch signaling in head and neck squamous cell carcinoma

C Porcheri, CT Meisel, T Mitsiadis - International journal of molecular …, 2019 - mdpi.com
Head and neck squamous cell carcinoma (HNSCC) defines a group of solid tumors
originating from the mucosa of the upper aerodigestive tract, pharynx, larynx, mouth, and …

Signaling and molecular pathways implicated in oral cancer: A concise review

M Kumari, BS Chhikara, P Singh… - Chemical Biology …, 2024 - pubs.thesciencein.org
Oral cancer is the sixth most prevalent type of cancer worldwide and third in India out of the
different cancer types identified. Mouth and oral cancers collectively refer to cancers of the …

Comprehending the crosstalk between Notch, Wnt and Hedgehog signaling pathways in oral squamous cell carcinoma-clinical implications

AP Patni, MK Harishankar, JP Joseph, B Sreeshma… - Cellular Oncology, 2021 - Springer
Background Oral squamous cell carcinoma (OSCC) is a malignant oral cavity neoplasm that
affects many people, especially in developing countries. Despite several advances that have …

Inhibition of CAL27 oral squamous carcinoma cell by targeting hedgehog pathway with vismodegib or itraconazole

RD Freitas, RB Dias, MTA Vidal, LF Valverde… - Frontiers in …, 2020 - frontiersin.org
Oral Squamous Cell Carcinoma (OSCC) presents an important challenge for the health
systems worldwide. Thus, unraveling the biological mechanisms involved in OSCC …

Exploring the potential of dietary factors and plant extracts as chemopreventive agents in oral squamous cell carcinoma treatment

M Kumar, AK Jha - Frontiers in Oral Health, 2023 - frontiersin.org
Oral cancer, particularly oral squamous cell carcinoma (OSCC), is a prevalent malignancy
having a significant fatality rate worldwide. Despite advancements in conventional treatment …

Noncalcemic vitamin D hydroxyderivatives inhibit human oral squamous cell carcinoma and down-regulate hedgehog and WNT/β-catenin pathways

ASW Oak, G Bocheva, TK Kim, AA Brożyna… - Anticancer …, 2020 - ar.iiarjournals.org
Background/Aim: The hormonally-active form of vitamin D, 1, 25 (OH) 2D3, demonstrated
activity against oral squamous cell carcinoma (OSCC). Cytochrome P450scc (CYP11A1) …

Doxorubicin combined with low intensity ultrasound suppresses the growth of oral squamous cell carcinoma in culture and in xenografts

H Fan, H Li, G Liu, W Cong, H Zhao, W Cao… - Journal of Experimental & …, 2017 - Springer
Background Oral squamous cell carcinoma (OSCC) invades surrounding tissues by
upregulating matrix metalloproteinases (MMPs)-2 and− 9, which causes over-expression of …

TRAIL, Wnt, sonic hedgehog, TGFβ, and miRNA signalings are potential targets for oral cancer therapy

AA Farooqi, CW Shu, HW Huang, HR Wang… - International Journal of …, 2017 - mdpi.com
Clinical studies and cancer cell models emphasize the importance of targeting therapies for
oral cancer. The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is highly …