The growing worldwide burden of insulin resistance (IR) emphasizes the importance of early
identification for improved management. Obesity, particularly visceral obesity, has been a …

Alzheimer's disease (AD), the most common form of neurodegenerative dementia in adults
worldwide, is a multifactorial and heterogeneous disorder characterized by the interaction of …

Mitochondrial oxidative stress plays an important role in the pathogenesis of Alzheimer's
disease (AD). Recently, antioxidant therapy has been considered an effective strategy for …

The onset and mechanisms underlying neurodegenerative diseases remain uncertain. The
main features of neurodegenerative diseases have been related with cellular and molecular …

Pathophysiology of chronic neurodegeneration is mainly based on complex mechanisms
related to aberrant signal transduction, excitation/inhibition imbalance, excitotoxicity …

Alzheimer's disease (AD) is one of the most common neurodegenerative diseases, and its
early onset is closely related to mitochondrial energy metabolism. The brain is only 2% of …

Alzheimer's Disease (AD) is a neurodegenerative disorder characterized by cognitive
impairment that increasingly affects the elderly. AD's main features have been related to …

Neuronal mitochondrial oxidative stress induced by β-amyloid (Aβ) is an early event of
Alzheimer's disease (AD). Emerging evidence has shown that antioxidant therapy …

Amyloid-beta (Aβ) peptides have a role in the pathogenesis of Alzheimer's disease (AD) and
are thought to promote oxidative stress, endoplasmic reticulum (ER) stress and …

Neurons are highly dependent on mitochondrial ATP production and Ca2+ buffering.
Neurons have unique compartmentalized anatomy and energy requirements, and each …