Immunometabolism and HIV-1 pathogenesis: food for thought
A Saez-Cirion, I Sereti - Nature reviews immunology, 2021 - nature.com
Antiretroviral therapies efficiently block HIV-1 replication but need to be maintained for life.
Moreover, chronic inflammation is a hallmark of HIV-1 infection that persists despite …
Moreover, chronic inflammation is a hallmark of HIV-1 infection that persists despite …
Immune responses in controllers of HIV infection
AK Kwaa, JN Blankson - Annual Review of Immunology, 2023 - annualreviews.org
Elite controllers are a heterogeneous group of people living with HIV who control viral
replication without antiretroviral therapy. There is substantial evidence that at least some …
replication without antiretroviral therapy. There is substantial evidence that at least some …
Reprogramming dysfunctional CD8+ T cells to promote properties associated with natural HIV control
F Perdomo-Celis, C Passaes… - The Journal of …, 2023 - Am Soc Clin Investig
Virus-specific CD8+ T cells play a central role in HIV-1 natural controllers to maintain
suppressed viremia in the absence of antiretroviral therapy. These cells display a memory …
suppressed viremia in the absence of antiretroviral therapy. These cells display a memory …
[HTML][HTML] Immune control of HIV
M Balasubramaniam, J Pandhare… - Journal of life sciences …, 2019 - ncbi.nlm.nih.gov
The human immunodeficiency virus (HIV) infection of the immune cells expressing the
cluster of differentiation 4 cell surface glycoprotein (CD4+ cells) causes progressive decline …
cluster of differentiation 4 cell surface glycoprotein (CD4+ cells) causes progressive decline …
Immune checkpoint molecules and glucose metabolism in HIV-induced T cell exhaustion
YT Chan, HC Cheong, TF Tang, R Rajasuriar… - Biomedicines, 2022 - mdpi.com
The progressive decline of CD8+ cytotoxic T cells in human immunodeficiency virus (HIV)-
infected patients due to infection-triggered cell exhaustion and cell death is significantly …
infected patients due to infection-triggered cell exhaustion and cell death is significantly …
Biological aging in people living with HIV on successful antiretroviral therapy: do they age faster?
SS Akusjärvi, U Neogi - Current HIV/AIDS Reports, 2023 - Springer
Abstract Purpose of Review In the absence of a prophylactic/therapeutic vaccine or cure, the
most amazing achievement in the battle against HIV was the discovery of effective, well …
most amazing achievement in the battle against HIV was the discovery of effective, well …
HIV-1 infection and glucose metabolism reprogramming of T cells: another approach toward functional cure and reservoir eradication
S Kang, H Tang - Frontiers in Immunology, 2020 - frontiersin.org
With the emerging of highly active antiretroviral therapy, HIV-1 infection has transferred from
a fatal threat to a chronic disease that could be managed. Nevertheless, inextricable …
a fatal threat to a chronic disease that could be managed. Nevertheless, inextricable …
Modulation of mTORC1 signaling pathway by HIV-1
Mammalian target of rapamycin complex 1 (mTORC1) is a master regulator of cellular
proliferation and survival which controls cellular response to different stresses, including …
proliferation and survival which controls cellular response to different stresses, including …
Immunological fingerprints of controllers developing neutralizing HIV-1 antibodies
The induction of broadly neutralizing antibodies (bnAbs) is highly desired for an effective
vaccine against HIV-1. Typically, bnAbs develop in patients with high viremia, but they can …
vaccine against HIV-1. Typically, bnAbs develop in patients with high viremia, but they can …
The integrated stress response signaling during the persistent HIV infection
Abstract Human immunodeficiency virus-1 (HIV) infection is a chronic disease under
antiretroviral therapy (ART), during which active HIV replication is effectively suppressed …
antiretroviral therapy (ART), during which active HIV replication is effectively suppressed …