Assessment of reference values for DNA damage detected by the comet assay in human blood cell DNA

P Møller - Mutation research/reviews in mutation research, 2006 - Elsevier
Genotoxicity measured by the comet assay is expressed by different researchers using
parameters that are not easy to conceptualize, except for percent tail DNA (% T) or visual …

Potential use of the comet assay in the clinical management of cancer

DJ McKenna, SR McKeown, VJ McKelvey-Martin - Mutagenesis, 2008 - academic.oup.com
The comet assay has been widely used to measure a range of cellular responses to DNA
damage and has found applications in genotoxicity studies, bio-monitoring, ecological …

[PDF][PDF] DNA damage and repair in lymphocytes of normal individuals and cancer patients: studies by the comet assay and micronucleus tests.

O Palyvoda, J Polańska, A Wygoda… - Acta Biochimica …, 2003 - frontierspartnerships.org
A population study is reported in which the DNA damage induced by g-radiation (2 Gy) and
the kinetics of the subsequent repair were estimated by the comet and micronucleus assays …

DNA damage induced in human peripheral blood lymphocytes by industrial solid waste and municipal sludge leachates

AA Bakare, AK Pandey, M Bajpayee… - Environmental and …, 2007 - Wiley Online Library
Exposure of humans to toxic compounds occurs mostly in the form of complex mixtures.
Leachates, consisting of mixtures of many chemicals, are a potential risk to human health. In …

DNA damage in lymphocytes of rural Indian women exposed to biomass fuel smoke as assessed by the Comet assay

AK Pandey, M Bajpayee, D Parmar… - Environmental and …, 2005 - Wiley Online Library
The Comet assay has found wide acceptance in monitoring human genotoxicity caused by
lifestyle and occupational and environmental factors. In the present study, we have used the …

Radiation sensitivity of leukocytes from healthy individuals and breast cancer patients as measured by the alkaline and neutral comet assay

M Shahidi, H Mozdarani, PE Bryant - Cancer letters, 2007 - Elsevier
Initial radiation-induced DNA damage, dose–response curves and kinetics of DNA repair in
leukocytes from healthy volunteers and breast cancer patients, was assessed using alkaline …

[PDF][PDF] Application of the comet assay method in clinical studies.

P Fikrová, R Štětina, M Hronek, R Hyšpler… - Wiener Klinische …, 2011 - researchgate.net
The comet assay or single-cell gel electrophoresis (SCGE) assay is now widely accepted as
a standard method for assessing DNA damage in individual cells. It finds use in a broad …

Evaluation of the effect of 90Sr β-radiation on human blood cells by chromosome aberration and single cell gel electrophoresis (comet assay) analysis

EM de Oliveira, MF Suzuki, PA do Nascimento… - Mutation Research …, 2001 - Elsevier
Among various environmental genotoxins, ionizing radiation has received special attention
because of its mutagenic, carcinogenic and teratogenic potential. In this context and …

DNA damage response and DNA repair–dog as a model?

N Grosse, B van Loon, C Rohrer Bley - BMC cancer, 2014 - Springer
Background Companion animals like dogs frequently develop tumors with age and similarly
to human malignancies, display interpatient tumoral heterogeneity. Tumors are frequently …

[HTML][HTML] Radiosensitivity and repair kinetics of gamma-irradiated leukocytes from sporadic prostate cancer patients and healthy individuals assessed by alkaline comet …

M Shahidi, H Mozdarani, WU Mueller - Iranian biomedical journal, 2010 - ncbi.nlm.nih.gov
Background: Impaired DNA repair mechanism is one of the main causes of tumor genesis.
Study of intrinsic radiosensitivity of cancer patients in a non-target tissue (eg peripheral …