Metabolic diseases, such as obesity, metabolic syndrome (MetS) and type 2 diabetes (T2D),
are now a widespread pandemic in the developed world. These pathologies show sex …

Testosterone is the main male sex hormone and is essential for the maintenance of male
secondary sexual characteristics and fertility. Androgen deficiency in young men owing to …

Direct diagnosis and accurate assessment of metabolic syndrome (MetS) allow for prompt
clinical interventions. However, traditional diagnostic strategies overlook the complex …

Sex hormone-binding globulin (SHBG) is the high-affinity binding protein for androgens and
estrogens. According to the free hormone hypothesis, SHBG modulates the bioactivity of sex …

Context: During aging, total testosterone (TT) declines and SHBG increases, resulting in a
greater decrease in calculated free T (cFT). Currently, guidelines suggest using TT to …

The aim of this work was to conduct a systematic review of human studies on metabolite/lipid
biomarkers of metabolic syndrome (MetS) and its components, and provide …

Objectives: In the absence of large, prospective, placebo-controlled studies of longer
duration, substantial evidence regarding the safety and risk of testosterone (T) therapy (TTh) …

This narrative review presents an overview of current knowledge on fertility and reproductive
hormone changes in aging men, the factors driving and modulating these changes, their …

Several large cohort studies have disclosed the trajectories of sex steroids changes
overtime in men and their clinical significance. In men the slow, physiological decline of …

Abstract Background Organophosphate esters (OPEs) are increasingly used as flame
retardants and plasticizers in various products. In vivo and in vitro studies suggest that OPEs …