Opioid-induced respiratory depression (OIRD) represents the primary cause of death
associated with therapeutic and recreational opioid use. Within the United States, the rate of …

Long-term hypercapnia is associated with respiratory conditions including obstructive sleep
apnea, chronic obstructive pulmonary disease and obesity hypoventilation syndrome …

Background Breathing disorders (BD)(apnoeas/hypopneas, periodic breathing) are highly
prevalent in chronic heart failure (CHF) and are associated with altered central respiratory …

Despite the prevalence of CO 2 retention in human disease, little is known about the
adaptive neurobiological effects of chronic hypercapnia. We have recently shown 30-d …

Ketamine is the recommended analgesic on the battlefield for soldiers with hemorrhage,
despite a lack of supportive evidence from laboratory or clinical studies. Hence, this study …

Chronic hypercapnia (CH) is a hallmark of respiratory diseases such as chronic obstructive
pulmonary disease. In such patients, mechanical ventilation is often used to restore normal …

Chronic hypercapnia (CH) is a hallmark of respiratory-related diseases, and the level of
hypercapnia can acutely or progressively become more severe. Previously, we have shown …

Cognitive impairment is associated with multiple human diseases that have in common
chronic hypercapnia. However, the mechanisms leading to chronic hypercapnia-induced …

This study was designed to investigate extrinsic tongue muscle activity in response to
bronchopulmonary C-fiber activation following midcervical spinal contusion in the rat …

The primary goal of the respiratory system is to match ventilation to metabolic rate, thus
maintaining blood gas homeostasis. Failure of the respiratory system to properly facilitate …