Camostat mesylate against SARS‐CoV‐2 and COVID‐19—Rationale, dosing and safety

P Breining, AL Frølund, JF Højen… - Basic & clinical …, 2021 - Wiley Online Library
The coronavirus responsible for COVID‐19, SARS‐CoV‐2, utilizes a viral membrane spike
protein for host cell entry. For the virus to engage in host membrane fusion, SARS‐CoV‐2 …

RNA interference-based therapy and its delivery systems

X Chen, LS Mangala, C Rodriguez-Aguayo… - Cancer and Metastasis …, 2018 - Springer
RNA interference (RNAi) is considered a highly specific approach for gene silencing and
holds tremendous potential for treatment of various pathologic conditions such as …

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

DE Gordon, GM Jang, M Bouhaddou, J Xu, K Obernier… - Nature, 2020 - nature.com
A newly described coronavirus named severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has …

Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review

P Csermely, T Korcsmáros, HJM Kiss, G London… - Pharmacology & …, 2013 - Elsevier
Despite considerable progress in genome-and proteome-based high-throughput screening
methods and in rational drug design, the increase in approved drugs in the past decade did …

Phosphoinositides: tiny lipids with giant impact on cell regulation

T Balla - Physiological reviews, 2013 - journals.physiology.org
Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Orally efficacious broad-spectrum ribonucleoside analog inhibitor of influenza and respiratory syncytial viruses

JJ Yoon, M Toots, S Lee, ME Lee… - Antimicrobial agents …, 2018 - Am Soc Microbiol
Morbidity and mortality resulting from influenza-like disease are a threat, especially for older
adults. To improve case management, next-generation broad-spectrum antiviral …

Computational investigation on Andrographis paniculata phytochemicals to evaluate their potency against SARS-CoV-2 in comparison to known antiviral compounds …

NA Murugan, CJ Pandian… - Journal of Biomolecular …, 2021 - Taylor & Francis
The outbreak due to SARS-CoV-2 (or Covid-19) is spreading alarmingly and number of
deaths due to infection is aggressively increasing every day. Due to the rapid human to …

Lost in deletion: The enigmatic ORF8 protein of SARS-CoV-2

L Zinzula - Biochemical and biophysical research communications, 2021 - Elsevier
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome contains nine
open reading frames (ORFs) that encode for accessory proteins which, although …

Potential Drugs Targeting Early Innate Immune Evasion of SARS-Coronavirus 2 via 2'-O-Methylation of Viral RNA

JA Encinar, JA Menendez - Viruses, 2020 - mdpi.com
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causing the COVID-19
respiratory disease pandemic utilizes unique 2′-o-methyltransferase (2′-O-MTase) …

In silico docking analysis revealed the potential of phytochemicals present in Phyllanthus amarus and Andrographis paniculata, used in Ayurveda medicine in …

S Hiremath, HDV Kumar, M Nandan, M Mantesh… - 3 Biotech, 2021 - Springer
The Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has resulted in
outbreak of global pandemic, fatal pneumonia in human referred as Coronavirus Disease …