Liver fibrosis is a major cause of morbidity and mortality worldwide due to chronic viral
hepatitis and, more recently, from fatty liver disease associated with obesity. Hepatic stellate …

HSCs (hepatic stellate cells)(also called vitamin A‐storing cells, lipocytes, interstitial cells, fat‐
storing cells or Ito cells) exist in the space between parenchymal cells and liver sinusoidal …

Depletion of peroxisome proliferator-activated receptor γ (PPARγ) accompanies
myofibroblastic transdifferentiation of hepatic stellate cells (HSC), the primary cellular event …

Past, present, and future research into hepatic stellate cells (HSCs, also called vitamin A-
storing cells, lipocytes, interstitial cells, fat-storing cells, or Ito cells) are summarized and …

The hepatic stellate cell (HSC) is now well established as the key cellular element involved
in the development of hepatic fibrosis and because of this there is considerable interest in …

Background & Aims: Factors influencing the progression of chronic hepatitis C virus (HCV)
infection are poorly understood. Monocyte chemotactic protein-1 (MCP-1) is a potent …

Background & Aims: The Forkhead box gene, group O (FoxO) family of Forkhead
transcription factors is phopsphorylated and inactivated by the phosphatidylinositol 3-kinase …

Hepatic stellate cell (HSC) activation is a process of cellular transdifferentiation in which,
upon liver injury, the quiescent vitamin A storing perisinusoidal HSC is converted into a …

leading to an understanding that is increasingly nuanced. A clear example is the paper of
Magness and coworkers1 in this issue of HEPATOLOGY, which explores the topic of stellate …

The transforming growth factor-beta (TGF-β) superfamily is one of the most diversified cell
signaling pathways and regulates many physiological and pathological processes …