The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis

Y Huang, W Hong, X Wei - Journal of hematology & oncology, 2022 - Springer
Epithelial–mesenchymal transition (EMT) is an essential process in normal embryonic
development and tissue regeneration. However, aberrant reactivation of EMT is associated …

Circulating tumor cells: biology and clinical significance

D Lin, L Shen, M Luo, K Zhang, J Li, Q Yang… - Signal transduction and …, 2021 - nature.com
Circulating tumor cells (CTCs) are tumor cells that have sloughed off the primary tumor and
extravasate into and circulate in the blood. Understanding of the metastatic cascade of CTCs …

Epithelial–mesenchymal transition: The history, regulatory mechanism, and cancer therapeutic opportunities

Z Huang, Z Zhang, C Zhou, L Liu, C Huang - MedComm, 2022 - Wiley Online Library
Epithelial–mesenchymal transition (EMT) is a program wherein epithelial cells lose their
junctions and polarity while acquiring mesenchymal properties and invasive ability …

[HTML][HTML] Emodin reduces breast cancer lung metastasis by suppressing macrophage-induced breast cancer cell epithelial-mesenchymal transition and cancer stem …

Q Liu, J Hodge, J Wang, Y Wang, L Wang, UP Singh… - Theranostics, 2020 - ncbi.nlm.nih.gov
Our previous studies demonstrated that the natural compound emodin blocks the tumor-
promoting feedforward interactions between cancer cells and macrophages, and thus …

Circulating tumour cells in the-omics era: how far are we from achieving the 'singularity'?

TH Visal, P den Hollander, M Cristofanilli… - British journal of …, 2022 - nature.com
Over the past decade, cancer diagnosis has expanded to include liquid biopsies in addition
to tissue biopsies. Liquid biopsies can result in earlier and more accurate diagnosis and …

[HTML][HTML] Epithelial-to-mesenchymal transition, circulating tumor cells and cancer metastasis: Mechanisms and clinical applications

XX Jie, XY Zhang, CJ Xu - Oncotarget, 2017 - ncbi.nlm.nih.gov
Epithelial-to-mesenchymal transition (EMT) endows epithelial cells with enhanced motility
and invasiveness, allowing them to participate in many physiological and pathological …

EMT-associated heterogeneity in circulating tumor cells: sticky friends on the road to metastasis

A Genna, AM Vanwynsberghe, AV Villard, C Pottier… - Cancers, 2020 - mdpi.com
Epithelial–mesenchymal transitions (EMTs) generate hybrid phenotypes with an enhanced
ability to adapt to diverse microenvironments encountered during the metastatic spread …

Epithelial-mesenchymal plasticity in circulating tumor cells

C Alix-Panabières, S Mader, K Pantel - Journal of Molecular Medicine, 2017 - Springer
Abstract Epithelial-to-Mesenchymal Transition (EMT) is a complex process that supports the
migratory capacity of epithelial tumor cells and is thought to play a crucial role in promoting …

Detection and clinical significance of circulating tumor cells in colorectal cancer

M Jiang, S Jin, J Han, T Li, J Shi, Q Zhong, W Li… - Biomarker …, 2021 - Springer
Histopathological examination (biopsy) is the “gold standard” for the diagnosis of colorectal
cancer (CRC). However, biopsy is an invasive method, and due to the temporal and spatial …

Survival mechanisms and influence factors of circulating tumor cells

WC Wang, XF Zhang, J Peng, XF Li… - BioMed research …, 2018 - Wiley Online Library
Circulating tumor cells (CTCs) are cancer cells shed from either the primary tumor or its
metastases that circulate in the peripheral blood. The CTCs are regarded as the source of …