Obesity is a complex multifactorial disease that accumulated excess body fat leads to
negative effects on health. Obesity continues to accelerate resulting in an unprecedented …

Obesity has become a global epidemic that has a negative impact on population health and
the economy of nations. Genetic predispositions have been demonstrated to have a …

The formation of adipocytes during embryogenesis has been largely understudied.
However, preadipocytes appear to originate from multipotent mesenchymal stromal/stem …

Recent insights into the pathophysiologic underlying mechanisms of obesity have led to the
discovery of several promising drug targets and novel therapeutic strategies to address the …

Obesity is a complex, heritable trait influenced by the interplay of genetics, epigenetics,
metagenomics and the environment. With the increasing access to high precision diagnostic …

Nowadays, obesity is one of the largest public health problems worldwide. In the last few
decades, there has been a marked increase in the obesity epidemic and its related …

Background: Obesity is known to be a multifactorial disease. In its pathogenesis, different
factors such as chronic inflammation, oxidative stress, insulin resistance, genetic factors …

Preadipocyte factor 1 (Pref-1, also called Dlk1/FA1) is a molecular gatekeeper of
adipogenesis which acts by maintaining the preadipocyte state and preventing adipocyte …

Obesity is a metabolic disease, which is becoming an epidemic health problem: it has been
recently defined in terms of Global Pandemic. Over the years, the approaches through …

Results: The average degree of DNA methylation of all analyzed CpG sites was lower in fat
cells from post-obese as compared with never-obese women (P= 0.014). A total of 8504 …