Toll-like receptor-guided therapeutic intervention of human cancers: molecular and immunological perspectives
Toll-like receptors (TLRs) serve as the body's first line of defense, recognizing both
pathogen-expressed molecules and host-derived molecules released from damaged or …
pathogen-expressed molecules and host-derived molecules released from damaged or …
Programmed cell death pathways as targets for developing antifilarial drugs: Lessons from the recent findings
NC Das, P Chakraborty, S Nandy, A Dey… - Journal of Cellular …, 2023 - Wiley Online Library
More than half a century has passed since the introduction of the National Filariasis Control
Program; however, as of 2023, lymphatic filariasis (LF) still prevails globally, particularly in …
Program; however, as of 2023, lymphatic filariasis (LF) still prevails globally, particularly in …
In silico analyses on the comparative sensing of SARS‐CoV‐2 mRNA by the intracellular TLRs of humans
Abstract The coronavirus disease‐2019 (COVID‐19) pandemic caused by severe acute
respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) has already resulted in a huge setback …
respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) has already resulted in a huge setback …
[HTML][HTML] Cell Surface Fibroblast Activation Protein-2 (Fap2) of Fusobacterium nucleatum as a Vaccine Candidate for Therapeutic Intervention of Human Colorectal …
Colorectal cancer (CRC) is one of the most common cancers and is the second-highest in
cancer-related deaths worldwide. The changes in gut homeostasis and microbial dysbiosis …
cancer-related deaths worldwide. The changes in gut homeostasis and microbial dysbiosis …
In Silico Analyses on the Comparative Potential of Therapeutic Human Monoclonal Antibodies Against Newly Emerged SARS-CoV-2 Variants Bearing Mutant Spike …
Since the start of the pandemic, SARS-CoV-2 has already infected more than 250 million
people globally, with more than five million fatal cases and huge socio-economic losses. In …
people globally, with more than five million fatal cases and huge socio-economic losses. In …
[HTML][HTML] Designing efficient multi-epitope peptide-based vaccine by targeting the antioxidant thioredoxin of bancroftian filarial parasite
Thioredoxin is a low molecular weight redox-active protein of filarial parasite that plays a
crucial role in downregulating the host immune response to prolong the survival of the …
crucial role in downregulating the host immune response to prolong the survival of the …
Helminth-derived biomacromolecules as therapeutic agents for treating inflammatory and infectious diseases: What lessons do we get from recent findings?
Despite the tremendous progress in healthcare sectors, a number of life-threatening
infectious, inflammatory, and autoimmune diseases are continuously challenging mankind …
infectious, inflammatory, and autoimmune diseases are continuously challenging mankind …
Reverse vaccinology assisted design of a novel multi-epitope vaccine to target Wuchereria bancrofti cystatin: An immunoinformatics approach
Proteases are the critical mediators of immunomodulation exerted by the filarial parasites to
bypass and divert host immunity. Cystatin is a small (∼ 15 kDa) immunomodulatory filarial …
bypass and divert host immunity. Cystatin is a small (∼ 15 kDa) immunomodulatory filarial …
Toll-like receptors (TLRs) as therapeutic targets for treating SARS-CoV-2: An immunobiological perspective
Abstract Introduction: Coronavirus disease-19 (COVID-19) caused by SARS-CoV-2 is
presently the biggest threat to mankind throughout the globe. Increasing reports on deaths …
presently the biggest threat to mankind throughout the globe. Increasing reports on deaths …
Construction and validation of a multi-epitope in silico vaccine model for lymphatic filariasis by targeting Brugia malayi: a reverse vaccinology approach
P Madanagopal, S Muthusamy, SN Pradhan… - Bulletin of the National …, 2023 - Springer
Background Lymphatic filariasis (LF), often referred to as elephantiasis, has been identified
as one of the 17 neglected tropical diseases by the World Health Organization. Currently …
as one of the 17 neglected tropical diseases by the World Health Organization. Currently …