Coronavirus disease 2019 (COVID-19) has caused an unprecedented global crisis and
continues to threaten public health. The etiological agent of this devastating pandemic …

Gas6 (growth arrest-specific gene 6) is a widely expressed vitamin K-dependent protein that
is involved in many biological processes such as homeostatic regulation, inflammation and …

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causing the COVID-19
respiratory disease pandemic utilizes unique 2′-o-methyltransferase (2′-O-MTase) …

Ruxolitinib is a selective inhibitor of Jak1/2. Downstream signaling pathways of Jak, such as
Stat3 and Akt/mTOR, are overactivated and contribute to renal interstitial fibrosis. Therefore …

Highlights•Axl/Gas6 are overexpressed in several cancer types.•Axl/Gas6 regulate the
epithelial-mesenchymal transition and cancer metastatic spread.•Axl/Gas6 are involved in …

Alterations in extracellular matrix (ECM) components that modulate inflammatory cell
behavior have been shown to serve as early starters for multifactorial diseases such as …

Epidemiological studies support a strong link between organ fibrosis and epithelial cancers.
Moreover, clinical and experimental investigations consistently indicate that these diseases …

Renal fibrosis is a progressive histological manifestation leading to chronic kidney disease
(CKD) and associated with mitochondrial dysfunction. In previous work, we showed that …

Background: Minimal change disease (MCD), a major cause of nephrotic syndrome, is
usually treated by corticosteroid administration. MCD unresponsiveness to therapy and …

Innate immune cells are important in the initiation and potentiation of alloimmunity in
transplantation. Immediately upon organ anastomosis and reperfusion, recipient monocytes …