Studying human nociceptors: from fundamentals to clinic

SJ Middleton, AM Barry, M Comini, Y Li, PR Ray… - Brain, 2021 - academic.oup.com
Chronic pain affects one in five of the general population and is the third most important
cause of disability-adjusted life-years globally. Unfortunately, treatment remains inadequate …

Advances in screening, early diagnosis and accurate staging of diabetic neuropathy

J Carmichael, H Fadavi, F Ishibashi… - Frontiers in …, 2021 - frontiersin.org
The incidence of both type 1 and type 2 diabetes is increasing worldwide. Diabetic
peripheral neuropathy (DPN) is among the most distressing and costly of all the chronic …

Early detection of diabetic peripheral neuropathy: a focus on small nerve fibres

J Burgess, B Frank, A Marshall, RS Khalil, G Ponirakis… - Diagnostics, 2021 - mdpi.com
Diabetic peripheral neuropathy (DPN) is the most common complication of both type 1 and 2
diabetes. As a result, neuropathic pain, diabetic foot ulcers and lower-limb amputations …

[PDF][PDF] Diagnosing diabetic neuropathy: something old, something new

IN Petropoulos, G Ponirakis, A Khan… - Diabetes & …, 2018 - synapse.koreamed.org
There are potentially many ways of assessing diabetic peripheral neuropathy (DPN).
However, they do not fulfill US Food and Drug Administration (FDA) requirements in relation …

Normative values for corneal nerve morphology assessed using corneal confocal microscopy: a multinational normative data set

M Tavakoli, M Ferdousi, IN Petropoulos, J Morris… - Diabetes …, 2015 - Am Diabetes Assoc
OBJECTIVE Corneal confocal microscopy is a novel diagnostic technique for the detection
of nerve damage and repair in a range of peripheral neuropathies, in particular diabetic …

An automatic tool for quantification of nerve fibers in corneal confocal microscopy images

X Chen, J Graham, MA Dabbah… - IEEE Transactions …, 2016 - ieeexplore.ieee.org
We describe and evaluate an automated software tool for nerve-fiber detection and
quantification in corneal confocal microscopy (CCM) images, combining sensitive nerve …

[HTML][HTML] Small fiber neuropathy in Parkinson's disease: a clinical, pathological and corneal confocal microscopy study

L Kass-Iliyya, S Javed, D Gosal, C Kobylecki… - Parkinsonism & related …, 2015 - Elsevier
Autonomic and somatic denervation is well established in Parkinson's disease (PD).
Objectives (1) To determine whether corneal confocal microscopy (CCM) can non-invasively …

Small‐fiber neuropathy: expanding the clinical pain universe

M Sopacua, JGJ Hoeijmakers… - Journal of the …, 2019 - Wiley Online Library
Small‐fiber neuropathy (SFN) is a disorder of thinly myelinated Aδ and unmyelinated C
fibers. SFN is clinically dominated by neuropathic pain and autonomic complaints, leading to …

Ocular involvement in hereditary amyloidosis

AM Minnella, R Rissotto, E Antoniazzi, M Di Girolamo… - Genes, 2021 - mdpi.com
The term amyloidosis describes a group of rare diseases caused by protein conformation
abnormalities resulting in extracellular deposition and accumulation of insoluble fibrillar …

Corneal confocal microscopy: ready for prime time

IN Petropoulos, G Ponirakis, A Khan… - Clinical and …, 2020 - Taylor & Francis
Corneal confocal microscopy is a non‐invasive ophthalmic imaging modality, which was
initially used for the diagnosis and management of corneal diseases. However, over the last …