Oncolytic virotherapy is a promising form of gene therapy for cancer, employing nature's own
agents to find and destroy malignant cells. The purpose of this review is to provide an …

Immunotherapy with immune checkpoint blockade (ICB) has shown limited benefits in
hepatocellular carcinoma (HCC) and other cancers, mediated in part by the …

Oncolytic adenoviruses (Ads) constitute a promising new class of anticancer agent. They are
based on the well-studied adenoviral vector system, which lends itself to concept-driven …

Loss of function in tumor suppressor genes is commonly associated with the
onset/progression of cancer and treatment resistance. The p53 tumor suppressor gene, a …

Oncolytic virotherapy is a promising alternative to conventional treatment, yet systemic
delivery of these viruses to tumors remains a major challenge. In this regard, mesenchymal …

Background Viral-mediated oncolysis is a novel cancer therapeutic approach with the
potential to be more effective and less toxic than current therapies due to the agents …

The repair of DNA double-strand breaks (DSBs) is a critical cellular mechanism that exists to
ensure genomic stability. DNA DSBs are the most deleterious type of insult to a cell's genetic …

Purpose: The incidence of malignant melanoma continues to increase worldwide; however,
treatment of metastatic melanoma remains unsatisfactory, and there is an urgent need for …

Simple Summary In normal cells, p53 is a protein which regulates the cell cycle progression
to ensure normal cell division, growth, and development. However, in cancer, changes in the …

Oncolytic virotherapy is the use of genetically engineered viruses that specifically target and
destroy tumor cells via their cytolytic replication cycle. Viral-mediated tumor destruction is …