Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities

M Bäck, A Yurdagul Jr, I Tabas, K Öörni… - Nature Reviews …, 2019 - nature.com
Atherosclerosis is a lipid-driven inflammatory disease of the arterial intima in which the
balance of pro-inflammatory and inflammation-resolving mechanisms dictates the final …

Omega-3 fatty acids and adipose tissue function in obesity and metabolic syndrome

L Martínez-Fernández, LM Laiglesia, AE Huerta… - Prostaglandins & other …, 2015 - Elsevier
The n-3 long-chain polyunsaturated fatty acids (n-3 PUFAs) such as eicosapentaenoic
(EPA) and docosahexaenoic (DHA) have been reported to improve obesity-associated …

[HTML][HTML] Perivascular adipose tissue–derived extracellular vesicle miR-221-3p mediates vascular remodeling

X Li, LL Ballantyne, Y Yu, CD Funk - The FASEB Journal, 2019 - ncbi.nlm.nih.gov
Adipose tissue–secreted extracellular vesicles (EVs) containing microRNAs (miRNAs)
convey intercellular message signaling. The biogenesis of EV-miRNAs from perivascular …

Inflammation and cardiovascular disease: are marine phospholipids the answer?

R Lordan, S Redfern, A Tsoupras, I Zabetakis - Food & function, 2020 - pubs.rsc.org
Since the discovery that Greenlandic Innuits had a lower risk of developing cardiovascular
diseases (CVD) due to their diet of fish and as a consequence high polyunsaturated fatty …

Eicosapentaenoic acid potentiates brown thermogenesis through FFAR4-dependent up-regulation of miR-30b and miR-378

J Kim, M Okla, A Erickson, T Carr, SK Natarajan… - Journal of biological …, 2016 - ASBMB
Emerging evidence suggests that n-3 polyunsaturated fatty acids (PUFA) promote brown
adipose tissue thermogenesis. However, the underlying mechanisms remain elusive. Here …

FFA4/GPR120: pharmacology and therapeutic opportunities

G Milligan, E Alvarez-Curto, BD Hudson… - Trends in …, 2017 - cell.com
Free Fatty Acid receptor 4 (FFA4), also known as GPR120, is a G-protein-coupled receptor
(GPCR) responsive to long-chain fatty acids that is attracting considerable attention as a …

Pharmacological modulation of immune responses by nutritional components

MT van Daal, G Folkerts, J Garssen, S Braber - Pharmacological Reviews, 2021 - ASPET
The incidence of noncommunicable diseases (NCDs) has increased over the last few
decades, and one of the major contributors to this is lifestyle, especially diet. High intake of …

Mechanistic insights into cardiovascular protection for omega-3 fatty acids and their bioactive lipid metabolites

TD O'Connell, RP Mason, MJ Budoff… - European Heart …, 2020 - academic.oup.com
Patients with well-controlled low-density lipoprotein cholesterol levels, but persistent high
triglycerides, remain at increased risk for cardiovascular events as evidenced by multiple …

Using Caenorhabditis elegans to Uncover Conserved Functions of Omega-3 and Omega-6 Fatty Acids

JL Watts - Journal of Clinical Medicine, 2016 - mdpi.com
The nematode Caenorhabditis elegans is a powerful model organism to study functions of
polyunsaturated fatty acids. The ability to alter fatty acid composition with genetic …

Nutritional considerations for peripheral arterial disease: a narrative review

CL Delaney, MK Smale, MD Miller - Nutrients, 2019 - mdpi.com
Those with peripheral arterial disease (PAD) require important considerations with respect
to food and nutrition, owing to advanced age, poor diet behaviours and immobility …