The evolving knowledge on primary hemostasis in patients with cirrhosis: a comprehensive review

A Zanetto, E Campello, M Senzolo, P Simioni - Hepatology, 2024 - journals.lww.com
Patients with cirrhosis develop complex alterations in primary hemostasis that include both
hypocoagulable and hypercoagulable features. This includes thrombocytopenia, multiple …

EASL Clinical Practice Guidelines on prevention and management of bleeding and thrombosis in patients with cirrhosis

E Villa, M Bianchini, A Blasi, A Denys, EG Giannini… - Journal of …, 2022 - Elsevier
The prevention and management of bleeding and thrombosis in patients with cirrhosis
poses several difficult clinical questions. These Clinical Practice Guidelines have been …

[HTML][HTML] Global hemostatic profiling in patients with decompensated cirrhosis and bacterial infections

A Zanetto, E Campello, C Bulato, S Gavasso… - JHEP Reports, 2022 - Elsevier
Background & Aims Bacterial infections in cirrhosis are associated with increased bleeding
risk. To assess the factors responsible for bleeding tendency in patients with bacterial …

[HTML][HTML] Safety of endoscopic retrograde cholangiopancreatography (ERCP) in cirrhosis compared to non-cirrhosis and effect of Child-Pugh score on post-ERCP …

ZI Tarar, U Farooq, M Gandhi, S Saleem… - Clinical …, 2023 - ncbi.nlm.nih.gov
Methods We conducted a literature search of relevant databases to identify studies that
reported post-ERCP complications in patients with hepatic cirrhosis. Results Twenty-four …

Profiling plasma alterations of extracellular vesicles in patients with acutely decompensated cirrhosis and bacterial infection

E Campello, A Zanetto, CM Radu, S Toffanin… - Liver …, 2024 - Wiley Online Library
Abstract Background Extracellular vesicles (EVs) modulate inflammation, coagulation and
vascular homeostasis in decompensated cirrhosis. Aim To characterize the profile of …

Anticoagulant therapy for splanchnic vein thrombosis: recent updates for patients with liver cirrhosis

LM Caiano, N Riva, W Ageno - Expert Review of Hematology, 2023 - Taylor & Francis
Introduction Liver cirrhosis is accompanied by several hemostatic alterations, which
contribute to the current theory of “rebalanced hemostasis.” Splanchnic vein thrombosis …

Predictors of early bleeding after endoscopic variceal ligation for esophageal varices: a systematic review and meta-analysis

S Giri, S Sundaram, V Jearth… - Clinical and Experimental …, 2022 - termedia.pl
Results A total of 16 studies with data on 13,378 patients were included in the meta-
analysis. Among 34 parameters, 14 parameters were assessed for association with early …

Hematologic disorders and the liver

BJ Wentworth, JB Miller, LE Carlini, SH Caldwell - Hepatology, 2025 - Elsevier
Acute and chronic liver disease is associated with significant hematologic disturbances.
Patients frequently develop multifactorial cytopenias and coagulopathy related to alterations …

Safety of Anticoagulation When Undergoing Endoscopic Variceal Ligation: A Systematic Review and Meta‐Analysis

JH Loo, JWE Quek, JTG Low, WX Tay, LS Ang… - Liver …, 2024 - Wiley Online Library
Introduction The safety of continuing anticoagulation therapy during endoscopic variceal
ligation (EVL) remains controversial. We performed a systematic review and meta‐analysis …

[HTML][HTML] The Bleeding Edge: Managing Coagulation and Bleeding Risk in Patients with Cirrhosis Undergoing Interventional Procedures

R Crăciun, C Grapă, T Mocan, C Tefas, I Nenu… - Diagnostics, 2024 - mdpi.com
This review addresses the peri-procedural bleeding risks in patients with cirrhosis,
emphasizing the need for careful coagulation assessment and targeted correction …