Over the last century, the alarming surge in allergy and autoimmune disease has led to the
hypothesis that decreasing exposure to microbes, which has accompanied industrialization …

Inflammation coordinates tissue regeneration via damaged cell removal and stem cell
activation. Hematopoietic stem cells (HSCs) survive inflammatory stress that kills other blood …

The journey of a hematopoietic stem cell (HSC) involves the passage through successive
anatomical sites where HSCs are in direct contact with their surrounding microenvironment …

Hematopoietic stem and progenitor cells (HSPCs) arise during embryonic development and
are essential for sustaining the blood and immune systems throughout life. Tight regulation …

Bone marrow (BM) stromal cells provide the regulatory framework for hematopoiesis and
contribute to developmental stage-specific niches, such as those preserving hematopoietic …

Haematopoietic stem cells (HSCs) are generated from haemogenic endothelial (HE) cells
via the formation of intra-aortic haematopoietic clusters (IAHCs) in vertebrate embryos. The …

Adult hematopoietic stem and progenitor cells (HSPCs) respond directly to inflammation and
infection, causing both acute and persistent changes to quiescence, mobilization, and …

Hematopoietic stem cells (HSCs) produce all lineages of mature blood cells for the lifetime
of an organism. In vertebrates, HSCs derive from the transition of the hemogenic …

Inflammatory signals arising from the microenvironment have emerged as critical regulators
of hematopoietic stem cell (HSC) function during diverse processes including embryonic …

Demand-adjusted and cell type specific rates of protein synthesis represent an important
safeguard for fate and function of long-term hematopoietic stem cells. Here, we identify …