Circadian rhythms are 24-h rhythms in physiology and behaviour generated by molecular
clocks, which serve to coordinate internal time with the external world. The circadian system …

Evidence is accumulating regarding the importance of circadian core oscillators, several
associated factors, and melatonin signaling in the maintenance of health. Dysfunction of …

Circadian rhythm disturbances are a common symptom among individuals with mood
disorders. The suprachiasmatic nucleus (SCN), in the ventral part of the anterior …

Melatonin is a pleiotropically acting regulator molecule, which influences numerous
physiological functions. Its secretion by the pineal gland progressively declines by age …

We describe the results of the first genome-wide association study (GWAS) of post-traumatic
stress disorder (PTSD) performed using trauma-exposed white non-Hispanic participants …

Bipolar disorder (BD) and major depressive disorder (MDD) are heritable neuropsychiatric
disorders associated with disrupted circadian rhythms. The hypothesis that circadian clock …

Substantial experimental evidence indicates a major role for the circadian system in mood
disorders. Additionally, proinflammatory cytokines have been proposed to be involved in the …

The serotonin and circadian systems are principal regulatory networks of the brain. Each
consists of a unique set of neurons that make widespread neural connections and a defined …

Background Abnormalities in the circadian clockwork often characterize patients with major
depressive and bipolar disorders. Circadian clock genes are targets of interest in these …

BACKGROUND:: Independent of temporal circumstances, some individuals have greater
susceptibility to depressive affects, such as feelings of guilt, sadness, hopelessness, and …