Oxidative stress, antioxidants and hypertension

M Amponsah-Offeh, P Diaba-Nuhoho, S Speier… - Antioxidants, 2023 - mdpi.com
As a major cause of morbidity and mortality globally, hypertension remains a serious threat
to global public health. Despite the availability of many antihypertensive medications …

Effects of alpha lipoic acid on metabolic syndrome: a comprehensive review

N Najafi, S Mehri… - Phytotherapy …, 2022 - Wiley Online Library
Metabolic syndrome (MetS) is a multifactorial disease with medical conditions such as
hypertension, diabetes, obesity, dyslipidemia, and insulin resistance. Alpha‐lipoic acid (α …

Clinical Relevance and Role of Neuronal AT1 Receptors in ADAM17-Mediated ACE2 Shedding in Neurogenic Hypertension

J Xu, S Sriramula, H Xia, L Moreno-Walton… - Circulation …, 2017 - Am Heart Assoc
Rationale: Neurogenic hypertension is characterized by an increase in sympathetic activity
and often resistance to drug treatments. We previously reported that it is also associated with …

Plant-food-derived bioactives in managing hypertension: From current findings to upcoming effective pharmacotherapies

M Butnariu, D Fratantonio… - Current topics in …, 2023 - ingentaconnect.com
A sedentary lifestyle has evoked a high risk of cardiovascular (CV) disease, diabetes, and
obesity, all of them with high morbimortality rates and with a common denominator …

A comprehensive guide to the pharmacologic regulation of angiotensin converting enzyme 2 (ACE2), the SARS-CoV-2 entry receptor

M Oz, DE Lorke, N Kabbani - Pharmacology & therapeutics, 2021 - Elsevier
The recent emergence of coronavirus disease-2019 (COVID-19) as a global pandemic has
prompted scientists to address an urgent need for defining mechanisms of disease …

[HTML][HTML] Dietary supplements, vitamins and minerals as potential interventions against viruses: Perspectives for COVID-19

MT Islam, C Quispe, M Martorell… - … Journal for Vitamin …, 2021 - econtent.hogrefe.com
The novel coronavirus (SARS-CoV-2) causing COVID-19 disease pandemic has infected
millions of people and caused more than thousands of deaths in many countries across the …

ACE2, Circumventricular Organs and the Hypothalamus, and COVID-19

WY Ong, RL Satish, DR Herr - NeuroMolecular Medicine, 2022 - Springer
The SARS-CoV-2 virus gains entry to cells by binding to angiotensin-converting enzyme 2
(ACE2). Since circumventricular organs and parts of the hypothalamus lack a blood–brain …

Antioxidant, anti-inflammatory, and immunomodulatory roles of nonvitamin antioxidants in anti-SARS-CoV-2 therapy

AM Pisoschi, F Iordache, L Stanca… - Journal of Medicinal …, 2022 - ACS Publications
Viral pathologies encompass activation of pro-oxidative pathways and inflammatory burst.
Alleviating overproduction of reactive oxygen species and cytokine storm in COVID-19 is …

ADAM17, a key player of cardiac inflammation and fibrosis in heart failure development during chronic catecholamine stress

J Adu-Amankwaah, GK Adzika, AO Adekunle… - Frontiers in Cell and …, 2021 - frontiersin.org
Heart failure development is characterized by persistent inflammation and progressive
fibrosis owing to chronic catecholamine stress. In a chronic stress state, elevated …

Role of ADAM and ADAMTS disintegrin and metalloproteinases in normal pregnancy and preeclampsia

H Qu, RA Khalil - Biochemical Pharmacology, 2022 - Elsevier
Normal pregnancy (NP) involves intricate processes starting with egg fertilization,
proceeding to embryo implantation, placentation and gestation, and culminating in …