Inflammatory and immune pathways in the pathogenesis of periodontal disease

A Cekici, A Kantarci, H Hasturk… - Periodontology …, 2014 - Wiley Online Library
The pathogenesis of periodontitis involves a complex immune/inflammatory cascade that is
initiated by the bacteria of the oral biofilm that forms naturally on the teeth. The susceptibility …

Biological markers for pulpal inflammation: a systematic review

DK Rechenberg, JC Galicia, OA Peters - PloS one, 2016 - journals.plos.org
Background and Objective Pulpitis is mainly caused by an opportunistic infection of the pulp
space with commensal oral microorganisms. Depending on the state of inflammation …

Pulp inflammation diagnosis from clinical to inflammatory mediators: a systematic review

M Zanini, E Meyer, S Simon - Journal of endodontics, 2017 - Elsevier
Introduction Similar to other tissues, the dental pulp mounts an inflammatory reaction as a
way to eliminate pathogens and stimulate repair. Pulp inflammation is prerequisite for dentin …

[HTML][HTML] Oral antimicrobial peptides: Types and role in the oral cavity

Z Khurshid, M Naseem, Z Sheikh, S Najeeb… - Saudi Pharmaceutical …, 2016 - Elsevier
Antimicrobial peptides (AMPs) are a wide-ranging class of host-defense molecules that act
early to contest against microbial invasion and challenge. These are small cationic peptides …

Innate immune responses of the dental pulp to caries

CL Hahn, FR Liewehr - Journal of endodontics, 2007 - Elsevier
Various cells and inflammatory mediators are involved in the initial pulpal responses to
caries. This review focuses on the cellular, neuronal, and vascular components of pulpal …

Molecular biomarkers for objective assessment of symptomatic pulpitis: A systematic review and meta‐analysis

RN Karrar, S Cushley, HF Duncan… - International …, 2023 - Wiley Online Library
Background Inflammatory biomarkers are potentially useful targets for pulpal diagnostic tests
that can identify pulp status and predict vital pulp treatment (VPT) outcome, however, their …

Neuropeptides in dental pulp: the silent protagonists

J Caviedes-Bucheli, HR Muñoz… - Journal of …, 2008 - Elsevier
Dental pulp is a soft mesenchymal tissue densely innervated by afferent (sensory) fibers,
sympathetic fibers, and parasympathetic fibers. This complexity in pulp innervation has …

Neuropeptides and neurogenic mechanisms in oral and periodontal inflammation

FT Lundy, GJ Linden - Critical Reviews in Oral Biology & …, 2004 - journals.sagepub.com
It is generally accepted that the nervous system contributes to the pathophysiology of
peripheral inflammation, and a neurogenic component has been implicated in many …

Potential applications of antimicrobial peptides and their mimics in combating caries and pulpal infections

S Mai, MT Mauger, L Niu, JB Barnes, S Kao… - Acta Biomaterialia, 2017 - Elsevier
Antimicrobial peptides (AMPs) are short cationic host-defense molecules that provide the
early stage of protection against invading microbes. They also have important modulatory …

Antimicrobial activity of neuropeptides against a range of micro-organisms from skin, oral, respiratory and gastrointestinal tract sites

IA El Karim, GJ Linden, DF Orr, FT Lundy - Journal of neuroimmunology, 2008 - Elsevier
Many neuropeptides are similar in size, amino acid composition and charge to antimicrobial
peptides. This study aimed to determine whether the neuropeptides substance P (SP) …