Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer's disease

Y Inoue, F Shue, G Bu, T Kanekiyo - Molecular neurodegeneration, 2023 - Springer
Vascular cognitive impairment and dementia (VCID) is commonly caused by vascular
injuries in cerebral large and small vessels and is a key driver of age-related cognitive …

Neurovascular coupling: motive unknown

PJ Drew - Trends in neurosciences, 2022 - cell.com
In the brain, increases in neural activity drive changes in local blood flow via neurovascular
coupling. The common explanation for increased blood flow (known as functional …

Migraine Aura, transient ischemic attacks, stroke, and dying of the brain share the same key pathophysiological process in neurons driven by Gibbs–Donnan forces …

CL Lemale, J Lückl, V Horst, C Reiffurth… - Frontiers in cellular …, 2022 - frontiersin.org
Neuronal cytotoxic edema is the morphological correlate of the near-complete neuronal
battery breakdown called spreading depolarization, or conversely, spreading depolarization …

Diurnal variation of brain activity in the human suprachiasmatic nucleus

S Oka, A Ogawa, T Osada, M Tanaka… - Journal of …, 2024 - Soc Neuroscience
The suprachiasmatic nucleus (SCN) is the central clock for circadian rhythms. Animal
studies have revealed daily rhythms in the neuronal activity in the SCN. However, the …

Blood flows from the SCN toward the OVLT within a new brain vascular portal pathway

RK Roy, Y Yao, IK Green, AV Aitken, VC Biancardi… - Science …, 2024 - science.org
The suprachiasmatic nucleus (SCN) sets the phase of oscillation throughout the brain and
body. Anatomical evidence reveals a portal system linking the SCN and the organum …

Angiotensin II–mediated neuroinflammation in the hippocampus contributes to neuronal deficits and cognitive impairment in heart failure rats

F Althammer, RK Roy, MK Kirchner, E Campos-Lira… - …, 2023 - Am Heart Assoc
Background: Heart failure (HF) is a debilitating disease affecting> 64 million people
worldwide. In addition to impaired cardiovascular performance and associated systemic …

High salt diet exacerbates cognitive deficits and neurovascular abnormalities in APP/PS1 mice and induces AD-like changes in wild-type mice

HC Chen, JX Cao, YS Zhang, YZ Ma, L Zhang… - The Journal of …, 2024 - Elsevier
High salt diet (HSD) is a risk factor of hypertension and cardiovascular disease. Although
clinical data do not clearly indicate the relationship between HSD and the prevalence of …

Parallel trajectories in the discovery of the SCN‐OVLT and pituitary portal pathways: Legacies of Geoffrey Harris

R Silver, Y Yao, RK Roy, JE Stern - Journal of …, 2023 - Wiley Online Library
A map of central nervous system organization based on vascular networks provides a layer
of organization distinct from familiar neural networks or connectomes. As a well‐established …

Toward an integrative neurovascular framework for studying brain networks

J Guilbert, A Légaré, P De Koninck… - …, 2022 - spiedigitallibrary.org
Brain functional connectivity based on the measure of blood oxygen level-dependent
(BOLD) functional magnetic resonance imaging (fMRI) signals has become one of the most …

Navigating Central Oxytocin Transport: Known Realms and Uncharted Territories

D Parmaksiz, Y Kim - The Neuroscientist, 2024 - journals.sagepub.com
Complex mechanisms govern the transport and action of oxytocin (Oxt), a neuropeptide and
hormone that mediates diverse physiologic processes. While Oxt exerts site-specific and …