New developments in RiPP discovery, enzymology and engineering

M Montalbán-López, TA Scott, S Ramesh… - Natural product …, 2021 - pubs.rsc.org
Covering: up to June 2020 Ribosomally-synthesized and post-translationally modified
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …

Mechanistic understanding of lanthipeptide biosynthetic enzymes

LM Repka, JR Chekan, SK Nair… - Chemical …, 2017 - ACS Publications
Lanthipeptides are ribosomally synthesized and post-translationally modified peptides
(RiPPs) that display a wide variety of biological activities, from antimicrobial to antiallodynic …

RiPP antibiotics: biosynthesis and engineering potential

GA Hudson, DA Mitchell - Current opinion in microbiology, 2018 - Elsevier
The threat of antibiotic resistant bacterial infections continues to underscore the need for
new treatment options. Historically, small molecule metabolites from microbes have …

Unrivalled diversity: the many roles and reactions of bacterial cytochromes P450 in secondary metabolism

A Greule, JE Stok, JJ De Voss, MJ Cryle - Natural product reports, 2018 - pubs.rsc.org
Covering: 2000 up to 2018 The cytochromes P450 (P450s) are a superfamily of heme-
containing monooxygenases that perform diverse catalytic roles in many species, including …

Precursor peptide-targeted mining of more than one hundred thousand genomes expands the lanthipeptide natural product family

MC Walker, SM Eslami, KJ Hetrick, SE Ackenhusen… - BMC genomics, 2020 - Springer
Background Lanthipeptides belong to the ribosomally synthesized and post-translationally
modified peptide group of natural products and have a variety of biological activities ranging …

YcaO-dependent posttranslational amide activation: biosynthesis, structure, and function

BJ Burkhart, CJ Schwalen, G Mann, JH Naismith… - Chemical …, 2017 - ACS Publications
With advances in sequencing technology, uncharacterized proteins and domains of
unknown function (DUFs) are rapidly accumulating in sequence databases and offer an …

Macrocyclization and backbone modification in RiPP biosynthesis

H Lee, WA Van Der Donk - Annual review of biochemistry, 2022 - annualreviews.org
The past decade has seen impressive advances in understanding the biosynthesis of
ribosomally synthesized and posttranslationally modified peptides (RiPPs). One of the most …

Atropopeptides are a novel family of ribosomally synthesized and posttranslationally modified peptides with a complex molecular shape

P Nanudorn, S Thiengmag, F Biermann… - Angewandte Chemie …, 2022 - Wiley Online Library
Biomacromolecules are known to feature complex three‐dimensional shapes that are
essential for their function. Among natural products, ambiguous molecular shapes are a rare …

Introduction to thiopeptides: biological activity, biosynthesis, and strategies for functional reprogramming

AA Vinogradov, H Suga - Cell Chemical Biology, 2020 - cell.com
Thiopeptides (also known as thiazolyl peptides) are structurally complex natural products
with rich biological activities. Known for over 70 years for potent killing of Gram-positive …

Bioinformatic expansion and discovery of thiopeptide antibiotics

CJ Schwalen, GA Hudson, B Kille… - Journal of the American …, 2018 - ACS Publications
Thiopeptides are members of the ribosomally synthesized and post-translationally modified
peptide family of natural products. Most characterized thiopeptides display nanomolar …