Spinal cord injury (SCI) is a life-shattering neurological condition that affects between
250,000 and 500,000 individuals each year with an estimated two to three million people …

Our brain serves as a center for cognitive function and neurons within the brain relay and
store information about our surroundings and experiences. Modulation of this complex …

Rho kinases (ROCKs), the first Rho effectors to be described, are serine/threonine kinases
that are important in fundamental processes of cell migration, cell proliferation and cell …

Rho kinase (ROCK) is a serine/threonine kinase and a downstream target of the small
GTPase Rho. The RhoA/ROCK pathway is associated with various neuronal functions such …

Acute traumatic spinal cord injury (SCI) results in a devastating loss of neurological function
below the level of injury and adversely affects multiple systems within the body. The …

Detailed pathophysiological findings of secondary damage phenomena after spinal cord
injury (SCI) as well as the identification of inhibitory and neurotrophic proteins have yielded …

It is widely known that ischemic stroke is the prominent cause of death and disability. To
date, neuroinflammation following ischemic stroke represents a complex event, which is an …

After a CNS injury in the adult mammals, axonal regeneration is very limited because of the
reduced intrinsic growth capacity and nonpermissive environment for axonal elongation …

Traumatic spinal cord injury (SCI) is associated with a lifetime of disability stemming from
loss of motor, sensory, and autonomic functions; these losses, along with increased …

Background The Rho pathway has been shown to have a role in the pathophysiology of
spinal cord injury (SCI). Upregulation of the Rho signaling pathway occurs as a result of SCI …