CD146 was originally identified as a melanoma cell adhesion molecule (MCAM) and highly
expressed in many tumors and endothelial cells. However, the evidence that CD146 acts as …

The progression of cancer is associated with alterations in the tumor microenvironment,
including changes in extracellular matrix (ECM) composition, matrix rigidity …

Background Multipotent mesenchymal stromal cells (MSCs) are precursors of various cell
types. Through soluble factors, direct cell–cell interactions and other intercellular …

Synthesis, deposition, and interactions of hyaluronan (HA) with its cellular receptor CD44
are crucial events that regulate the onset and progression of tumors. The intracellular …

Laminins are composed of three polypeptide chains, designated as α, β, and γ. The C-
terminal region of laminin heterotrimers, containing coiled-coil regions, short tails, and …

Laminins are large heterotrimers composed of the α, β and γ subunits with distinct tissue-
specific and developmentally regulated expression patterns. The laminin-α2 subunit …

Impairment of normal hematopoiesis and leukemia progression are 2 well-linked processes
during leukemia development and are controlled by the bone marrow (BM) niche …

For metastasis formation, individual cells from a primary tumor must migrate toward other
tissues. The aim of this study was to determine if mesenchymal stromal cells (MSCs) from …

There is an unmet need for the treatment of glioblastoma multiforme (GBM). The
extracellular matrix, including laminins, in the tumor microenvironment is important for tumor …

The fundamental role of cell adhesion molecules in mediating various biological processes
as angiogenesis has been well-documented. CD146, an adhesion molecule of the …