Young-onset colorectal cancer

MCW Spaander, AG Zauber, S Syngal… - Nature reviews Disease …, 2023 - nature.com
In the past decades the incidence of colorectal cancer (CRC) in people under the age of 50
years has increased, which is referred to as early-onset CRC or young-onset CRC (YO …

[HTML][HTML] Birth cohort colorectal cancer (CRC): implications for research and practice

S Gupta, FP May, SS Kupfer, CC Murphy - Clinical Gastroenterology and …, 2024 - Elsevier
Colorectal cancer (CRC) epidemiology is changing due to a birth cohort effect, first
recognized by increasing incidence of early onset CRC (EOCRC, age< 50 years). In this …

The microbiome and rise of early-onset cancers: knowledge gaps and research opportunities

K Mima, T Hamada, K Inamura, H Baba, T Ugai… - Gut …, 2023 - Taylor & Francis
Accumulating evidence indicates an alarming increase in the incidence of early-onset
cancers, which are diagnosed among adults under 50 years of age, in the colorectum …

Prognostic role of detailed colorectal location and tumor molecular features: analyses of 13,101 colorectal cancer patients including 2994 early-onset cases

T Ugai, N Akimoto, K Haruki, TA Harrison… - Journal of …, 2023 - Springer
Background The pathogenic effect of colorectal tumor molecular features may be influenced
by several factors, including those related to microbiota, inflammation, metabolism, and …

Fusobacterium nucleatum promotes tumor progression in KRAS p.G12D-mutant colorectal cancer by binding to DHX15

H Zhu, M Li, D Bi, H Yang, Y Gao, F Song… - Nature …, 2024 - nature.com
Fusobacterium nucleatum (F. nucleatum) promotes intestinal tumor growth and its relative
abundance varies greatly among patients with CRC, suggesting the presence of unknown …

[HTML][HTML] Hereditary colorectal Cancer syndromes and inflammatory bowel diseases: risk management and surveillance strategies

L Brandaleone, A Dal Buono, R Gabbiadini… - Cancers, 2024 - mdpi.com
Simple Summary Hereditary colorectal cancer syndromes (HCCS) and inflammatory bowel
disease (IBD) carry a high risk of developing colorectal cancer (CRC). The co-occurrence of …

The histological and molecular characteristics of early-onset colorectal cancer: a systematic review and meta-analysis

T Lawler, L Parlato, S Warren Andersen - Frontiers in Oncology, 2024 - frontiersin.org
Background: Early-onset colorectal cancer (CRC), defined as diagnosis before age 50, has
increased in recent decades. Although more often diagnosed at advanced stage …

Early-Onset Colorectal Cancer: Molecular Underpinnings Accelerating Occurrence

A Zinkeng, FL Taylor, SH Cheong, H Song… - Cellular and Molecular …, 2024 - Elsevier
The onset of colorectal cancer (CRC) in patients under 50 continues to rapidly increase. This
study highlights the epidemiological changes, risk factors, clinical characteristics, and …

[HTML][HTML] Early-onset gastrointestinal cancer: An epidemiological reality with great significance and implications

JK Triantafillidis, K Georgiou… - World Journal of …, 2024 - ncbi.nlm.nih.gov
During the last few years, epidemiological data from many countries suggest that the
incidence and prevalence of many cancers of the digestive system are shifting from the older …

Colon Polyp Surveillance–Separating the Wheat from the Chaff

BA Sullivan, DA Lieberman - Gastroenterology, 2024 - Elsevier
Unstructured Abstract One goal of colorectal cancer (CRC) screening is to prevent CRC
incidence by removing precancerous colonic polyps, which are detected in up to 50% of …