Pre-diabetes and diabetes are a global epidemic, and the associated neuropathic
complications create a substantial burden on both the afflicted patients and society as a …

The effective and safe treatment of pain is an unmet health-care need. Current medications
used for pain management are often only partially effective, carry dose-limiting adverse …

Membrane ion channels are the fundamental electrical components in the nervous system.
Recent developments in X-ray crystallography and cryo-EM microscopy have revealed what …

The somatosensory system allows us to detect a diverse range of physical and chemical
stimuli including noxious ones, which can initiate protective reflexes to prevent tissue …

Saltatory conduction of action potentials along myelinated axons depends on the nodes of
Ranvier—small unmyelinated axonal domains where voltage-gated sodium channels are …

A variety of mechanosensory neurons are involved in touch, proprioception, and pain. Many
molecular components of the mechanotransduction machinery subserving these sensory …

Abstract Na V 1.7, a subtype of the voltage-gated sodium channel family that is highly
expressed in peripheral sensory neurons, remains one of the most promising targets for the …

Reactive oxygen species (ROS)-activated proinflammatory signals in keratinocytes play a
crucial role in the immunoregulation of inflammatory skin diseases, including rosacea and …

Acute pain is adaptive, but chronic pain is a global challenge. Many chronic pain syndromes
are peripheral in origin and reflect hyperactivity of peripheral pain-signaling neurons …

Current treatments for chronic pain rely largely on opioids despite their substantial side
effects and risk of addiction. Genetic studies have identified in humans key targets pivotal to …