Snakebite envenoming

JM Gutiérrez, JJ Calvete, AG Habib… - Nature reviews Disease …, 2017 - nature.com
Snakebite envenoming is a neglected tropical disease that kills> 100,000 people and
maims> 400,000 people every year. Impoverished populations living in the rural tropics are …

Neurotoxicity in snakebite—the limits of our knowledge

UK Ranawaka, DG Lalloo… - PLoS neglected tropical …, 2013 - journals.plos.org
Snakebite is classified by the WHO as a neglected tropical disease. Envenoming is a
significant public health problem in tropical and subtropical regions. Neurotoxicity is a key …

Phospholipases A2: unveiling the secrets of a functionally versatile group of snake venom toxins

JM Gutiérrez, B Lomonte - Toxicon, 2013 - Elsevier
Phospholipases A2 (PLA2s) are abundant components of snake venoms, where they play
toxic and digestive roles. Despite having a similar three-dimensional structure, venom …

Cytotoxicity of snake venom enzymatic toxins: phospholipase A2 and l-amino acid oxidase

JJ Hiu, MKK Yap - Biochemical society transactions, 2020 - portlandpress.com
The phospholipase A2 (PLA2) and l-amino acid oxidase (LAAO) are two major enzymes
found in the venoms from most snake species. These enzymes have been structurally and …

The urgent need to develop novel strategies for the diagnosis and treatment of snakebites

HF Williams, HJ Layfield, T Vallance, K Patel… - Toxins, 2019 - mdpi.com
Snakebite envenoming (SBE) is a priority neglected tropical disease, which kills in excess of
100,000 people per year. Additionally, many millions of survivors also suffer through …

Secreted Phospholipases A2 of Snake Venoms: Effects on the Peripheral Neuromuscular System with Comments on the Role of Phospholipases A2 in Disorders of …

JB Harris, T Scott-Davey - Toxins, 2013 - mdpi.com
Neuro-and myotoxicological signs and symptoms are significant clinical features of
envenoming snakebites in many parts of the world. The toxins primarily responsible for the …

[HTML][HTML] Snake venom cytotoxins, phospholipase A2s, and Zn2+-dependent metalloproteinases: mechanisms of action and pharmacological relevance

SE Gasanov, RK Dagda, ED Rael - Journal of clinical toxicology, 2014 - ncbi.nlm.nih.gov
Snake venom toxins are responsible for causing severe pathology and toxicity following
envenomation including necrosis, apoptosis, neurotoxicity, myotoxicity, cardiotoxicity …

[PDF][PDF] Phospholipases A2 from viperidae snake venoms: how do they induce skeletal muscle damage?

B Lomonte, JM Gutiérrez - 2011 - researchgate.net
Abstract Phospholipases A2 (PLA2s) are abundant components in snake venoms, which
play important toxic roles. This review focuses on group II PLA2s endowed with myotoxic …

Mitochondrial alarmins released by degenerating motor axon terminals activate perisynaptic Schwann cells

E Duregotti, S Negro, M Scorzeto… - Proceedings of the …, 2015 - National Acad Sciences
An acute and highly reproducible motor axon terminal degeneration followed by complete
regeneration is induced by some animal presynaptic neurotoxins, representing an …

Bothrops snake myotoxins induce a large efflux of ATP and potassium with spreading of cell damage and pain

M Cintra-Francischinelli, P Caccin… - Proceedings of the …, 2010 - National Acad Sciences
Myotoxins play a major role in the pathogenesis of the envenomations caused by snake
bites in large parts of the world where this is a very relevant public health problem. We show …