Background: Thiazole is a good pharmacophore nucleus due to its various pharmaceutical
applications. Its derivatives have a wide range of biological activities such as antioxidant …

A bidirectional relationship exists between hypertension and psychiatric disorders, including
unipolar and bipolar depression, anxiety, post-traumatic stress disorder (PTSD), psychosis …

Abstract Carbonic anhydrases (CAs, EC 4.2. 1.1) are crucial metalloenzymes involved in
many bioprocesses, through catalysis of the reversible hydration/dehydration process of CO …

Carbonic anhydrases (CAs) are important regulators of pH homeostasis and participate in
many physiological and pathological processes. CA activators (CAAs) are becoming …

There is a substantial unmet need for effective and patient-acceptable drugs to treat severe
mental illnesses such as schizophrenia (SZ). Computational analysis of genomic …

A series of novel tetrahydroquinoline derivatives containing urea moiety was synthesized
and their in vitro inhibitory effects on the human carbonic anhydrase isoenzymes (hCA− I …

Cardiovascular diseases are the leading cause of mortality worldwide. In recent years, the
relationship between carbonic anhydrase inhibitors and atherosclerosis has attracted …

Objective: Carbonic anhydrase (CA), 6-phosphogluconate dehydrogenase (6PGD) and
thioredoxin reductase (TrxR) enzymes are the essential biological molecules needed for …

Background Computational pharmacology can uniquely address some issues in the process
of drug development by providing a macroscopic view and a deeper understanding of drug …

Carbonic anhydrase is a ubiquitous metalloenzyme that catalyzes the reversible
interconversion of CO2/HCO3−. Equilibrium of these species is maintained by the action of …