Antisense oligonucleotides: an emerging area in drug discovery and development
Antisense oligonucleotides (ASOs) bind sequence specifically to the target RNA and
modulate protein expression through several different mechanisms. The ASO field is an …
modulate protein expression through several different mechanisms. The ASO field is an …
Small and long non-coding RNAs: Past, present, and future
LL Chen, VN Kim - Cell, 2024 - cell.com
Since the introduction of the central dogma of molecular biology in 1958, various RNA
species have been discovered. Messenger RNAs transmit genetic instructions from DNA to …
species have been discovered. Messenger RNAs transmit genetic instructions from DNA to …
Interplay between MAPK/ERK signaling pathway and MicroRNAs: A crucial mechanism regulating cancer cell metabolism and tumor progression
Mitogen-activated protein kinase (MAPK) signal transduction, as a highly conserved
signaling pathway, is reported to be involved in various biological events, including …
signaling pathway, is reported to be involved in various biological events, including …
MicroRNAs and other non-coding RNAs as targets for anticancer drug development
The first cancer-targeted microRNA (miRNA) drug—MRX34, a liposome-based miR-34
mimic—entered Phase I clinical trials in patients with advanced hepatocellular carcinoma in …
mimic—entered Phase I clinical trials in patients with advanced hepatocellular carcinoma in …
Cobomarsen, an oligonucleotide inhibitor of miR‐155, co‐ordinately regulates multiple survival pathways to reduce cellular proliferation and survival in cutaneous T …
AG Seto, X Beatty, JM Lynch… - British journal of …, 2018 - Wiley Online Library
Summary miR‐155, a microRNA associated with poor prognosis in lymphoma and
leukaemia, has been implicated in the progression of mycosis fungoides (MF), the most …
leukaemia, has been implicated in the progression of mycosis fungoides (MF), the most …
Macrophage polarization and meta-inflammation
Chronic overnutrition and obesity induces low-grade inflammation throughout the body.
Termed “meta-inflammation,” this chronic state of inflammation is mediated by macrophages …
Termed “meta-inflammation,” this chronic state of inflammation is mediated by macrophages …
MicroRNAs in cancer
G Di Leva, M Garofalo, CM Croce - Annual Review of Pathology …, 2014 - annualreviews.org
MicroRNAs (miRNAs) are small noncoding RNAs that typically inhibit the translation and
stability of messenger RNAs (mRNAs), controlling genes involved in cellular processes such …
stability of messenger RNAs (mRNAs), controlling genes involved in cellular processes such …
MicroRNA: function, detection, and bioanalysis
Mature microRNAs (miRNAs) are a class of evolutionally conserved, single-stranded, small
(approximately 19− 23 nucleotides), endogenously expressed, and non-protein-coding …
(approximately 19− 23 nucleotides), endogenously expressed, and non-protein-coding …
MiR-155: an important regulator of neuroinflammation
VD Zingale, A Gugliandolo, E Mazzon - International Journal of Molecular …, 2021 - mdpi.com
MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression
at the post-transcriptional level and that play an important role in many cellular processes …
at the post-transcriptional level and that play an important role in many cellular processes …
MicroRNAs: history, biogenesis, and their evolving role in animal development and disease
M Bhaskaran, M Mohan - Veterinary pathology, 2014 - journals.sagepub.com
The discovery of microRNAs (miRNAs) in 1993 followed by developments and discoveries
in small RNA biology have redefined the biological landscape by significantly altering the …
in small RNA biology have redefined the biological landscape by significantly altering the …