In response to a wide range of stimulations, host cells activate pyroptosis, a kind of
inflammatory cell death which is provoked by the cytosolic sensing of danger signals and …

Reactive oxygen species (ROS) are critical for the progression of cardiovascular diseases,
inflammations and tumors. However, the mechanisms of how ROS sense metabolic stress …

In addition to the roles of endothelial cells (ECs) in physiological processes, ECs actively
participate in both innate and adaptive immune responses. We previously reported that, in …

Pyroptosis is a pro-inflammatory form of regulated cell death and is dependent on the
enzymatic activity of inflammatory proteases that belong to the family of cysteine-dependent …

Pyroptosis is a form of programmed necrosis, and is morphologically and mechanistically
unique form of programmed cell death compared to others, such as apoptosis and …

Pyroptosis is a form of programmed cell death activated by various stimuli and is
characterized by inflammasome assembly, membrane pore formation, and the secretion of …

Pyroptosis is a programmed necrotic cell death executed by gasdermins, a family of pore-
forming proteins. The cleavage of gasdermins by specific proteases enables their pore …

Pyroptosis is a kind of pro-inflammatory cell death. Compared with autophagy and
apoptosis, pyroptosis has unique characteristics in morphology and mechanism …

Non-apoptotic regulated cell death (RCD) is essential to maintain organismal homeostasis
and may be aberrantly activated during certain pathological states. Lipids are emerging as …

Atherosclerosis is a chronic inflammatory disorder characterized by the gradual buildup of
plaques within the vessel wall of middle-sized and large arteries. The occurrence and …